FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term chemical synaptic transmission ID (Ontology) GO:0007268 (Gene Ontology)
Definition The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      78
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Relevant FlyBase reports
 Genes
 chemical synaptic transmission (all annotations which use CV term, excluding "NOT" statements)      78
     involved_in | chemical synaptic transmission      78
 NOT | involved_in | chemical synaptic transmission       1
Spanning Tree (Parents/Children)
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  trans-synaptic signaling
   |__anterograde trans-synaptic signaling
       |__chemical synaptic transmission  322 rec.
           |__excitatory chemical synaptic transmission
           |__inhibitory chemical synaptic transmission
           |__neuromuscular synaptic transmission 78 rec.
           |   |__synaptic transmission involved in micturition
           |__neuron-neuron synaptic transmission 15 rec.
           |__positive regulation of synapse maturation by synaptic transmission
           |__spontaneous synaptic transmission
           |__synaptic transmission, cholinergic 34 rec.
           |__synaptic transmission, dopaminergic 6 rec.
           |__synaptic transmission, GABAergic 7 rec.
           |__synaptic transmission, glutamatergic 31 rec.
           |__synaptic transmission, glycinergic 3 rec.
           |__synaptic transmission, noradrenergic
           |__synaptic transmission, serotonergic
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Is a anterograde trans-synaptic signaling
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Synonyms
  • "neurotransmission" RELATED
    "signal transmission across a synapse" BROAD
    "synaptic transmission" BROAD
Secondary IDs
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Reactome:R-HSA-112316 "Neuronal System"
Reactome:R-HSA-442720 "CREB1 phosphorylation through the activation of Adenylate Cyclase"
Reactome:R-HSA-442729 "CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"
Reactome:R-HSA-442742 "CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"
Reactome:R-HSA-451307 "Activation of Na-permeable kainate receptors"
Reactome:R-HSA-451308 "Activation of Ca-permeable Kainate Receptor"
Reactome:R-HSA-9619229 "Activation of RAC1 downstream of NMDARs"
Reactome:R-HSA-9619483 "Activation of AMPK downstream of NMDARs"
Reactome:R-HSA-9620244 "Long-term potentiation"
Wikipedia:Neurotransmission