General Information
Term	cell death	ID (Ontology)	GO:0008219 (Gene Ontology)
Definition	Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).[ PubMed:25236395 ]
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General Information

Term

cell death

ID (Ontology)

GO:0008219 (Gene Ontology)

Definition

Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).[ PubMed:25236395 ]

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

  biological_process
   |__cellular process
       |__cell death  388 rec.
           |__programmed cell death 388 rec.
               |__apoptotic process(+) 303 rec.
               |__autolysis
               |__autophagic cell death 26 rec.
               |__cornification
               |__cuproptosis
               |__ferroptosis
               |__programmed cell death in response to reactive oxygen species(+)
               |__programmed cell death in response to retinoic acid
               |__programmed cell death involved in cell development(+) 80 rec.
               |__programmed necrotic cell death(+) 5 rec.
               |__pyroptotic cell death(+)
               |__symbiont-induced defense-related programmed cell death(+)

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Is a	cellular process
Part of
Synonyms & Secondary IDs
Synonyms
	"accidental cell death" RELATED "necrosis" RELATED
Secondary IDs

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Is a

cellular process

Part of

Synonyms & Secondary IDs

Synonyms

"accidental cell death" RELATED
"necrosis" RELATED

Secondary IDs

External Crossreferences & Linkouts