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General Information
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| Term |
IkappaB kinase complex |
ID (Ontology) |
GO:0008385 (Gene Ontology) |
| Definition |
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.[ PubMed:12055104 PubMed:20300203 ] |
| Also Known As |
"heterotrimeric IKK complex" ; "IKK complex" ; "trimeric IKK complex" |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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| Data Class | Field | Records |
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| Genes (FBgn) | GO_CELLULAR_COMPONENT | 1 |
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Genes |
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IkappaB kinase complex (all annotations which use CV term, excluding "NOT" statements) | 1 | part_of | IkappaB kinase complex | 1 |
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Relationships
