FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of signal transduction ID (Ontology) GO:0009968 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.
Also Known As "down regulation of signal transduction" ; "down-regulation of signal transduction" ; "downregulation of signal transduction"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       3
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 negative regulation of signal transduction (all annotations which use CV term, excluding "NOT" statements)       3
     involved_in | negative regulation of signal transduction       3
Spanning Tree (Parents/Children)
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signal transduction
 |__regulation of signal transduction____________
regulation of cell communication                 |
 |__regulation of signal transduction____________|
 |__negative regulation of cell communication____|
regulation of signaling                          |
 |__regulation of signal transduction____________|
 |__negative regulation of signaling_____________|
negative regulation of biological process        |
 |__negative regulation of signaling_____________|
 |__negative regulation of response to stimulus__|
negative regulation of cellular process          |
 |__negative regulation of cell communication____|
regulation of response to stimulus               |
 |__regulation of signal transduction____________|
 |__negative regulation of response to stimulus__|
                                                 negative regulation of signal transduction  459 rec.
                                                  |__extracellular negative regulation of signal transduction
                                                  |   |__sequestering of extracellular ligand from receptor(+)
                                                  |__negative adaptation of signaling pathway 4 rec.
                                                  |   |__adaptation to pheromone regulating conjugation with mutual genetic exchange
                                                  |   |__desensitization of G protein-coupled receptor signaling pathway(+) 4 rec.
                                                  |   |__negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation
                                                  |__negative regulation of abscisic acid-activated signaling pathway
                                                  |__negative regulation of antigen receptor-mediated signaling pathway
                                                  |   |__negative regulation of B cell receptor signaling pathway
                                                  |   |__negative regulation of T cell receptor signaling pathway(+)
                                                  |__negative regulation of apolipoprotein A-I-mediated signaling pathway
                                                  |__negative regulation of apoptotic signaling pathway 22 rec.
                                                  |   |__negative regulation of apoptosome assembly
                                                  |   |__negative regulation of extrinsic apoptotic signaling pathway(+) 3 rec.
                                                  |   |__negative regulation of intrinsic apoptotic signaling pathway(+) 6 rec.
                                                  |   |__negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 1 rec.
                                                  |   |__negative regulation of release of cytochrome c from mitochondria 2 rec.
                                                  |__negative regulation of auxin mediated signaling pathway
                                                  |__negative regulation of brain-derived neurotrophic factor receptor signaling pathway
                                                  |__negative regulation of brassinosteroid mediated signaling pathway
                                                  |__negative regulation of CD40 signaling pathway
                                                  |__negative regulation of corticotropin-releasing hormone receptor activity
                                                  |__negative regulation of cytokine activity
                                                  |   |__negative regulation of chemokine activity
                                                  |__negative regulation of cytokine-mediated signaling pathway 6 rec.
                                                  |   |__negative regulation of chemokine-mediated signaling pathway(+)
                                                  |   |__negative regulation of interleukin-1-mediated signaling pathway
                                                  |   |__negative regulation of interleukin-2-mediated signaling pathway
                                                  |   |__negative regulation of interleukin-4-mediated signaling pathway
                                                  |   |__negative regulation of interleukin-6-mediated signaling pathway
                                                  |   |__negative regulation of interleukin-17-mediated signaling pathway
                                                  |   |__negative regulation of interleukin-18-mediated signaling pathway
                                                  |   |__negative regulation of interleukin-27-mediated signaling pathway
                                                  |   |__negative regulation of interleukin-35-mediated signaling pathway
                                                  |   |__negative regulation of Kit signaling pathway
                                                  |   |__negative regulation of macrophage colony-stimulating factor signaling pathway
                                                  |   |__negative regulation of macrophage migration inhibitory factor signaling pathway
                                                  |   |__negative regulation of prolactin signaling pathway
                                                  |   |__negative regulation of tumor necrosis factor-mediated signaling pathway 6 rec.
                                                  |   |__negative regulation of type I interferon-mediated signaling pathway
                                                  |   |__negative regulation of type II interferon-mediated signaling pathway
                                                  |__negative regulation of cytokinin-activated signaling pathway
                                                  |__negative regulation of ephrin receptor signaling pathway
                                                  |__negative regulation of ERBB signaling pathway 40 rec.
                                                  |   |__negative regulation of epidermal growth factor receptor signaling pathway(+) 40 rec.
                                                  |   |__negative regulation of ERBB3 signaling pathway
                                                  |   |__negative regulation of ERBB4 signaling pathway
                                                  |__negative regulation of Fas signaling pathway
                                                  |__negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
                                                  |__negative regulation of fibroblast growth factor receptor signaling pathway 9 rec.
                                                  |   |__negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
                                                  |   |__negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
                                                  |__negative regulation of G protein-coupled receptor signaling pathway 20 rec.
                                                  |   |__desensitization of G protein-coupled receptor signaling pathway(+) 4 rec.
                                                  |   |__G protein-coupled receptor catabolic process
                                                  |   |__negative regulation of adenosine receptor signaling pathway
                                                  |   |__negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway(+) 2 rec.
                                                  |   |__negative regulation of angiotensin-activated signaling pathway
                                                  |   |__negative regulation of chemokine-mediated signaling pathway(+)
                                                  |   |__negative regulation of dopamine receptor signaling pathway(+)
                                                  |   |__negative regulation of octopamine or tyramine signaling pathway(+)
                                                  |   |__negative regulation of opioid receptor signaling pathway(+)
                                                  |   |__negative regulation of opsin-mediated signaling pathway(+) 15 rec.
                                                  |   |__negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway(+) 5 rec.
                                                  |   |__negative regulation of thrombin-activated receptor signaling pathway
                                                  |   |__termination of G protein-coupled receptor signaling pathway
                                                  |__negative regulation of GDF15-GFRAL signaling pathway
                                                  |__negative regulation of gibberellic acid mediated signaling pathway
                                                  |__negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                  |__negative regulation of glucose mediated signaling pathway
                                                  |   |__negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway
                                                  |__negative regulation of glutamate receptor signaling pathway
                                                  |__negative regulation of growth hormone receptor signaling pathway
                                                  |__negative regulation of hepatocyte growth factor receptor signaling pathway
                                                  |__negative regulation of insulin receptor signaling pathway 32 rec.
                                                  |   |__negative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                  |__negative regulation of insulin-like growth factor receptor signaling pathway 1 rec.
                                                  |__negative regulation of integrin-mediated signaling pathway
                                                  |__negative regulation of intracellular signal transduction 153 rec.
                                                  |   |__negative regulation of calcium-mediated signaling(+)
                                                  |   |__negative regulation of cAMP/PKA signal transduction 7 rec.
                                                  |   |__negative regulation of canonical NF-kappaB signal transduction 3 rec.
                                                  |   |__negative regulation of cell cycle checkpoint(+) 1 rec.
                                                  |   |__negative regulation of cytoplasmic pattern recognition receptor signaling pathway(+)
                                                  |   |__negative regulation of endoplasmic reticulum unfolded protein response(+) 2 rec.
                                                  |   |__negative regulation of hippo signaling 51 rec.
                                                  |   |__negative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                  |   |__negative regulation of intracellular steroid hormone receptor signaling pathway(+) 3 rec.
                                                  |   |__negative regulation of intrinsic apoptotic signaling pathway(+) 6 rec.
                                                  |   |__negative regulation of MAPK cascade(+) 53 rec.
                                                  |   |__negative regulation of nitric oxide mediated signal transduction(+)
                                                  |   |__negative regulation of non-canonical NF-kappaB signal transduction
                                                  |   |__negative regulation of peroxisome proliferator activated receptor signaling pathway
                                                  |   |__negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 11 rec.
                                                  |   |__negative regulation of phospholipase C/protein kinase C signal transduction
                                                  |   |__negative regulation of phosphorelay signal transduction system(+)
                                                  |   |__negative regulation of protein kinase C signaling
                                                  |   |__negative regulation of retinoic acid receptor signaling pathway
                                                  |   |__negative regulation of signal transduction by p53 class mediator(+) 2 rec.
                                                  |   |__negative regulation of SMAD protein signal transduction 1 rec.
                                                  |   |__negative regulation of small GTPase mediated signal transduction(+) 8 rec.
                                                  |   |__negative regulation of SREBP signaling pathway(+)
                                                  |   |__negative regulation of stress-activated protein kinase signaling cascade(+) 3 rec.
                                                  |   |__negative regulation of thyroid hormone receptor signaling pathway
                                                  |   |__negative regulation of TOR signaling(+) 23 rec.
                                                  |   |__negative regulation of vitamin D receptor signaling pathway
                                                  |__negative regulation of lipopolysaccharide-mediated signaling pathway
                                                  |   |__tolerance induction to lipopolysaccharide
                                                  |__negative regulation of netrin-activated signaling pathway
                                                  |__negative regulation of neuronal signal transduction 1 rec.
                                                  |__negative regulation of neurotrophin TRK receptor signaling pathway
                                                  |__negative regulation of Notch signaling pathway 45 rec.
                                                  |   |__negative regulation of Notch signaling pathway involved in somitogenesis
                                                  |__negative regulation of peptidoglycan recognition protein signaling pathway 47 rec.
                                                  |__negative regulation of platelet-derived growth factor receptor signaling pathway
                                                  |   |__negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
                                                  |   |__negative regulation of platelet-derived growth factor receptor-beta signaling pathway
                                                  |__negative regulation of receptor guanylyl cyclase signaling pathway
                                                  |__negative regulation of receptor signaling pathway via STAT 21 rec.
                                                  |   |__negative regulation of receptor signaling pathway via JAK-STAT(+) 21 rec.
                                                  |__negative regulation of red or far-red light signaling pathway
                                                  |__negative regulation of Roundabout signaling pathway
                                                  |   |__termination of Roundabout signal transduction
                                                  |__negative regulation of semaphorin-plexin signaling pathway 1 rec.
                                                  |__negative regulation of sevenless signaling pathway 6 rec.
                                                  |__negative regulation of signal transduction by receptor internalization
                                                  |   |__negative regulation of insulin receptor signaling pathway by insulin receptor internalization
                                                  |__negative regulation of signal transduction in absence of ligand 1 rec.
                                                  |   |__negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 1 rec.
                                                  |__negative regulation of signal transduction involved in conjugation with cellular fusion
                                                  |   |__negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion
                                                  |__negative regulation of smoothened signaling pathway 60 rec.
                                                  |   |__negative regulation of hh target transcription factor activity
                                                  |   |__negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
                                                  |   |__negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
                                                  |__negative regulation of sphingolipid mediated signaling pathway
                                                  |__negative regulation of Toll signaling pathway 20 rec.
                                                  |__negative regulation of toll-like receptor 1 signaling pathway
                                                  |__negative regulation of toll-like receptor 2 signaling pathway
                                                  |__negative regulation of toll-like receptor 4 signaling pathway
                                                  |__negative regulation of toll-like receptor 5 signaling pathway
                                                  |__negative regulation of toll-like receptor 6 signaling pathway
                                                  |__negative regulation of toll-like receptor 10 signaling pathway
                                                  |__negative regulation of toll-like receptor 15 signaling pathway
                                                  |__negative regulation of toll-like receptor signaling pathway
                                                  |   |__negative regulation of MyD88-dependent toll-like receptor signaling pathway
                                                  |   |__negative regulation of MyD88-independent toll-like receptor signaling pathway
                                                  |   |__negative regulation of toll-like receptor 21 signaling pathway
                                                  |__negative regulation of torso signaling pathway 8 rec.
                                                  |__negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 46 rec.
                                                  |   |__negative regulation of activin receptor signaling pathway(+) 3 rec.
                                                  |   |__negative regulation of anti-Mullerian hormone signaling pathway
                                                  |   |__negative regulation of BMP signaling pathway(+) 43 rec.
                                                  |   |__negative regulation of SMAD protein signal transduction 1 rec.
                                                  |   |__negative regulation of transforming growth factor beta receptor signaling pathway(+)
                                                  |__negative regulation of vascular endothelial growth factor receptor signaling pathway 8 rec.
                                                  |__negative regulation of vascular endothelial growth factor signaling pathway
                                                  |__negative regulation of Wnt signaling pathway 53 rec.
                                                  |   |__negative regulation of canonical Wnt signaling pathway 51 rec.
                                                  |   |__negative regulation of non-canonical Wnt signaling pathway(+)
                                                  |   |__negative regulation of Wnt signaling pathway involved in heart development
                                                  |   |__Wnt receptor catabolic process
                                                  |__termination of signal transduction
                                                      |__termination of G protein-coupled receptor signaling pathway
                                                      |__termination of Roundabout signal transduction
                                                      |__termination of T cell signal transduction
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Is a regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
negative regulation of response to stimulus
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Synonyms
  • "down regulation of signal transduction" EXACT
    "down-regulation of signal transduction" EXACT
    "downregulation of signal transduction" EXACT
    "inhibition of signal transduction" NARROW
    "negative regulation of signaling pathway" RELATED
    "negative regulation of signalling pathway" RELATED
Secondary IDs
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Reactome:R-HSA-8849472 "PTK6 Down-Regulation"