FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term negative regulation of macromolecule biosynthetic process ID (Ontology) GO:0010558 (Gene Ontology)
Definition Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available
Spanning Tree (Parents/Children)
Only view relationship: 
macromolecule biosynthetic process
 |__regulation of macromolecule biosynthetic process________
regulation of biosynthetic process                          |
 |__negative regulation of biosynthetic process_____________|
 |__regulation of macromolecule biosynthetic process________|
negative regulation of metabolic process                    |
 |__negative regulation of biosynthetic process_____________|
 |__negative regulation of macromolecule metabolic process__|
regulation of macromolecule metabolic process               |
 |__regulation of macromolecule biosynthetic process________|
 |__negative regulation of macromolecule metabolic process__|
                                                            negative regulation of macromolecule biosynthetic process  929 rec.
                                                             |__negative regulation of (1->3)-beta-D-glucan biosynthetic process
                                                             |__negative regulation of cellulose biosynthetic process
                                                             |   |__negative regulation of plant-type cell wall cellulose biosynthetic process
                                                             |__negative regulation of cutin biosynthetic process
                                                             |__negative regulation of DNA biosynthetic process
                                                             |   |__negative regulation of DNA amplification
                                                             |   |__negative regulation of error-prone translesion synthesis
                                                             |   |__negative regulation of reverse transcription
                                                             |   |__negative regulation of telomere maintenance via telomerase
                                                             |__negative regulation of gene expression 660 rec.
                                                             |   |__mRNA catabolic process(+) 138 rec.
                                                             |   |__mRNA destabilization(+) 68 rec.
                                                             |   |__negative regulation of cytokine production(+) 2 rec.
                                                             |   |__negative regulation of gene expression, epigenetic(+) 217 rec.
                                                             |   |__negative regulation of miRNA processing(+) 3 rec.
                                                             |   |__negative regulation of oxytocin production
                                                             |   |__negative regulation of production of molecular mediator of immune response(+) 20 rec.
                                                             |   |__negative regulation of protein maturation(+) 6 rec.
                                                             |   |__negative regulation of RNA splicing(+) 8 rec.
                                                             |   |__negative regulation of rRNA processing
                                                             |   |__negative regulation of snoRNA processing
                                                             |   |__negative regulation of translation(+) 85 rec.
                                                             |   |__negative regulation of tRNA processing
                                                             |   |__post-transcriptional gene silencing(+) 211 rec.
                                                             |   |__programmed DNA elimination(+)
                                                             |   |__regulatory ncRNA-mediated gene silencing(+) 263 rec.
                                                             |   |__transcriptional attenuation(+)
                                                             |   |__transposable element silencing(+) 45 rec.
                                                             |__negative regulation of glycogen biosynthetic process 1 rec.
                                                             |__negative regulation of glycoprotein biosynthetic process 1 rec.
                                                             |   |__negative regulation of amyloid precursor protein biosynthetic process 1 rec.
                                                             |   |__negative regulation of protein O-linked glycosylation
                                                             |   |__negative regulation of proteoglycan biosynthetic process
                                                             |__negative regulation of hemoglobin biosynthetic process
                                                             |__negative regulation of hyaluronan biosynthetic process
                                                             |__negative regulation of integrin biosynthetic process
                                                             |   |__negative regulation of beta 2 integrin biosynthetic process
                                                             |__negative regulation of MHC class I biosynthetic process
                                                             |__negative regulation of MHC class II biosynthetic process
                                                             |__negative regulation of protein lipidation
                                                             |   |__negative regulation of N-terminal protein palmitoylation
                                                             |   |__negative regulation of peptidyl-L-cysteine S-palmitoylation
                                                             |__negative regulation of RNA biosynthetic process 322 rec.
                                                             |   |__negative regulation of DNA-templated transcription(+) 322 rec.
                                                             |   |__negative regulation of promoter clearance from RNA polymerase II promoter
                                                             |   |__negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
                                                             |__negative regulation of starch biosynthetic process
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a negative regulation of biosynthetic process
regulation of macromolecule biosynthetic process
negative regulation of macromolecule metabolic process
Part of
hide Synonyms & Secondary IDs
Synonyms
Secondary IDs
hide External Crossreferences & Linkouts