FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term negative regulation of macromolecule metabolic process ID (Ontology) GO:0010605 (Gene Ontology)
Definition Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available
Spanning Tree (Parents/Children)
Only view relationship: 
regulation of metabolic process
 |__negative regulation of metabolic process_______
 |__regulation of macromolecule metabolic process__|
negative regulation of cellular process            |
 |__negative regulation of metabolic process_______|
                                                   negative regulation of macromolecule metabolic process  1000 rec.
                                                    |__negative regulation of cell wall polysaccharide catabolic process
                                                    |   |__negative regulation of mannan catabolic process
                                                    |   |__negative regulation of plant-type cell wall cellulose catabolic process
                                                    |__negative regulation of cellodextrin catabolic process
                                                    |__negative regulation of cellulose catabolic process
                                                    |__negative regulation of cyclodextrin catabolic process
                                                    |__negative regulation of DNA metabolic process 44 rec.
                                                    |   |__negative regulation of DNA biosynthetic process(+)
                                                    |   |__negative regulation of DNA catabolic process(+)
                                                    |   |__negative regulation of DNA recombination(+) 28 rec.
                                                    |   |__negative regulation of DNA repair(+) 2 rec.
                                                    |   |__negative regulation of DNA replication(+) 14 rec.
                                                    |   |__negative regulation of meiotic DNA double-strand break formation(+)
                                                    |   |__negative regulation of mitochondrial DNA metabolic process(+) 1 rec.
                                                    |   |__negative regulation of mitotic recombination-dependent replication fork processing
                                                    |   |__negative regulation of t-circle formation 1 rec.
                                                    |   |__negative regulation of telomere maintenance(+)
                                                    |__negative regulation of galactoglucomannan catabolic process
                                                    |__negative regulation of galactomannan catabolic process
                                                    |__negative regulation of glucomannan catabolic process
                                                    |__negative regulation of glycogen metabolic process 4 rec.
                                                    |   |__negative regulation of glycogen biosynthetic process 1 rec.
                                                    |   |__negative regulation of glycogen catabolic process 3 rec.
                                                    |__negative regulation of hemicellulose catabolic process
                                                    |   |__negative regulation of xylan catabolic process(+)
                                                    |   |__negative regulation of xyloglucan catabolic process
                                                    |__negative regulation of macromolecule biosynthetic process 929 rec.
                                                    |   |__negative regulation of (1->3)-beta-D-glucan biosynthetic process
                                                    |   |__negative regulation of cellulose biosynthetic process(+)
                                                    |   |__negative regulation of cutin biosynthetic process
                                                    |   |__negative regulation of DNA biosynthetic process(+)
                                                    |   |__negative regulation of gene expression(+) 660 rec.
                                                    |   |__negative regulation of glycogen biosynthetic process 1 rec.
                                                    |   |__negative regulation of glycoprotein biosynthetic process(+) 1 rec.
                                                    |   |__negative regulation of hemoglobin biosynthetic process
                                                    |   |__negative regulation of hyaluronan biosynthetic process
                                                    |   |__negative regulation of integrin biosynthetic process(+)
                                                    |   |__negative regulation of MHC class I biosynthetic process
                                                    |   |__negative regulation of MHC class II biosynthetic process
                                                    |   |__negative regulation of protein lipidation(+)
                                                    |   |__negative regulation of RNA biosynthetic process(+) 322 rec.
                                                    |   |__negative regulation of starch biosynthetic process
                                                    |__negative regulation of pectin catabolic process
                                                    |__negative regulation of protein metabolic process 140 rec.
                                                    |   |__negative regulation of amyloid fibril formation
                                                    |   |__negative regulation of amyloid precursor protein catabolic process(+)
                                                    |   |__negative regulation of glycoprotein metabolic process(+) 1 rec.
                                                    |   |__negative regulation of granulocyte macrophage colony-stimulating factor production
                                                    |   |__negative regulation of hemoglobin biosynthetic process
                                                    |   |__negative regulation of hepatocyte growth factor production
                                                    |   |__negative regulation of lipoprotein metabolic process(+)
                                                    |   |__negative regulation of lymphotoxin A production
                                                    |   |__negative regulation of protein catabolic process(+) 18 rec.
                                                    |   |__negative regulation of protein maturation(+) 6 rec.
                                                    |   |__negative regulation of protein modification process(+) 8 rec.
                                                    |   |__negative regulation of proteolysis(+) 44 rec.
                                                    |   |__negative regulation of translation(+) 85 rec.
                                                    |__negative regulation of receptor catabolic process
                                                    |   |__negative regulation of low-density lipoprotein particle receptor catabolic process
                                                    |__negative regulation of receptor recycling 3 rec.
                                                    |__negative regulation of RNA metabolic process 340 rec.
                                                    |   |__negative regulation of miRNA metabolic process(+)
                                                    |   |__negative regulation of mRNA metabolic process(+) 15 rec.
                                                    |   |__negative regulation of RNA biosynthetic process(+) 322 rec.
                                                    |   |__negative regulation of RNA catabolic process(+) 14 rec.
                                                    |   |__negative regulation of rRNA processing
                                                    |   |__negative regulation of snoRNA metabolic process(+)
                                                    |   |__negative regulation of snRNA pseudouridine synthesis
                                                    |   |__negative regulation of tRNA metabolic process(+) 1 rec.
                                                    |__negative regulation of starch catabolic process
                                                        |__negative regulation of amylopectin catabolic process
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a negative regulation of metabolic process
regulation of macromolecule metabolic process
Part of
hide Synonyms & Secondary IDs
Synonyms
Secondary IDs
hide External Crossreferences & Linkouts