FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term myotube differentiation ID (Ontology) GO:0014902 (Gene Ontology)
Definition The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.
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  muscle cell differentiation
   |__striated muscle cell differentiation
       |__myotube differentiation  38 rec.
           |__myoblast fusion 38 rec.
           |   |__myoblast fusion involved in skeletal muscle regeneration
           |   |__regulation of myoblast fusion(+) 9 rec.
           |__myotube cell development
           |   |__myotube cell development involved in skeletal muscle regeneration
           |   |__skeletal muscle fiber development(+)
           |__myotube differentiation involved in skeletal muscle regeneration
           |   |__myoblast fusion involved in skeletal muscle regeneration
           |   |__myotube cell development involved in skeletal muscle regeneration
           |__regulation of myotube differentiation
           |   |__negative regulation of myotube differentiation(+)
           |   |__positive regulation of myotube differentiation(+)
           |   |__regulation of skeletal muscle fiber development(+)
           |   |__regulation of skeletal muscle fiber differentiation(+)
           |__skeletal muscle fiber differentiation
               |__regulation of skeletal muscle fiber differentiation(+)
               |__tongue muscle cell differentiation(+)
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Is a striated muscle cell differentiation
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