FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term heparan sulfate proteoglycan biosynthetic process ID (Ontology) GO:0015012 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of heparan sulfate proteoglycans, which consist of a core protein linked to a heparan sulfate glycosaminoglycan. The heparan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-alpha-(1,4)-hexuronic acid, the former being either sulfated or deacetylated on its amino group as well as sulfated on one of its hydroxyl groups, and the latter being e a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids. Heparan sulfate chains are covalently linked to serine/threonine residues (O-linked) of the core protein via a tetrasaccharide linker sequence (xylose-galactose-galactose-glucuronate).[ PubMed:27241222 ]
Also Known As "heparan sulfate proteoglycan anabolism" ; "heparan sulfate proteoglycan biosynthesis" ; "heparan sulfate proteoglycan formation" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      17
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 Gene Groups Genes
 heparan sulfate proteoglycan biosynthetic process (all annotations which use CV term, excluding "NOT" statements)       2     17
     involved_in | heparan sulfate proteoglycan biosynthetic process       --      17
Spanning Tree (Parents/Children)
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proteoglycan metabolic process
 |__proteoglycan biosynthetic process_______________
 |__heparan sulfate proteoglycan metabolic process__|
protein O-linked glycosylation                      |
 |__protein O-linked glycosylation via xylose_______|
glycoprotein biosynthetic process                   |
 |__proteoglycan biosynthetic process_______________|
                                                    heparan sulfate proteoglycan biosynthetic process  19 rec.
                                                     |__glycosaminoglycan-protein linkage region biosynthetic process 4 rec.
                                                     |__regulation of heparan sulfate proteoglycan biosynthetic process
                                                         |__positive regulation of heparan sulfate proteoglycan biosynthetic process
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Is a proteoglycan biosynthetic process
heparan sulfate proteoglycan metabolic process
protein O-linked glycosylation via xylose
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Synonyms
  • "heparan sulfate proteoglycan anabolism" EXACT
    "heparan sulfate proteoglycan biosynthesis" EXACT
    "heparan sulfate proteoglycan formation" EXACT
    "heparan sulfate proteoglycan synthesis" EXACT
    "heparan sulphate proteoglycan biosynthesis" EXACT
    "heparan sulphate proteoglycan biosynthetic process" EXACT
    "heparin proteoglycan biosynthetic process" RELATED
Secondary IDs
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MetaCyc:PWY-6558
Reactome:R-HSA-2022928 "HS-GAG biosynthesis"