FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term post-transcriptional gene silencing ID (Ontology) GO:0016441 (Gene Ontology)
Definition The inactivation of gene expression that occurs after transcription.[ PubMed:15020054 ]
Also Known As "posttranscriptional gene silencing" ; "PTGS"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       7
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 post-transcriptional gene silencing (all annotations which use CV term, excluding "NOT" statements)       7
     involved_in | post-transcriptional gene silencing       7
Spanning Tree (Parents/Children)
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regulation of gene expression
 |__post-transcriptional regulation of gene expression_____
 |__negative regulation of gene expression_________________|
negative regulation of macromolecule biosynthetic process  |
 |__negative regulation of gene expression_________________|
                                                           post-transcriptional gene silencing  211 rec.
                                                            |__global gene silencing by mRNA cleavage 3 rec.
                                                            |__regulation of post-transcriptional gene silencing 14 rec.
                                                            |   |__negative regulation of post-transcriptional gene silencing(+) 9 rec.
                                                            |   |__positive regulation of post-transcriptional gene silencing(+) 3 rec.
                                                            |   |__regulation of post-transcriptional gene silencing by regulatory ncRNA(+) 12 rec.
                                                            |__regulatory ncRNA-mediated post-transcriptional gene silencing 204 rec.
                                                            |   |__lncRNA-mediated post-transcriptional gene silencing 1 rec.
                                                            |   |__lsiRNA processing
                                                            |   |__miRNA-mediated post-transcriptional gene silencing(+) 167 rec.
                                                            |   |__piRNA-mediated gene silencing by mRNA destabilization(+) 12 rec.
                                                            |   |__regulation of post-transcriptional gene silencing by regulatory ncRNA(+) 12 rec.
                                                            |   |__RNAi-mediated antiviral immune response(+) 5 rec.
                                                            |   |__siRNA-mediated post-transcriptional gene silencing(+) 1 rec.
                                                            |   |__sRNA-mediated post-transcriptional gene silencing
                                                            |   |__transitive RNA interference(+)
                                                            |__target-directed miRNA degradation 6 rec.
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Is a post-transcriptional regulation of gene expression
negative regulation of gene expression
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Synonyms
  • "posttranscriptional gene silencing" EXACT
    "PTGS" EXACT
Secondary IDs
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Wikipedia:Post_transcriptional_gene_silencing