FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term NuRD complex ID (Ontology) GO:0016581 (Gene Ontology)
Definition An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins.[ PubMed:10589671 PubMed:11743021 PubMed:17289569 ]
Also Known As "NRD complex" ; "nucleosome remodeling and histone deacetylation complex"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       8
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Relevant FlyBase reports
 Gene Groups Genes
 NuRD complex (all annotations which use CV term, excluding "NOT" statements)       1      8
     part_of | NuRD complex       --       8
Spanning Tree (Parents/Children)
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protein-containing complex
 |__transcription regulator complex__
SWI/SNF superfamily-type complex     |
 |__CHD-type complex_________________|
nuclear protein-containing complex   |
 |__histone deacetylase complex______|
catalytic complex                    |
 |__histone deacetylase complex______|
                                     NuRD complex  9 rec.
                                      |__SHREC complex
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Is a histone deacetylase complex
transcription regulator complex
CHD-type complex
Part of
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Synonyms
  • "Mi-2 complex" NARROW
    "NRD complex" EXACT
    "nucleosome remodeling and histone deacetylation complex" EXACT
Secondary IDs
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