FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative cofactor 2 complex ID (Ontology) GO:0017054 (Gene Ontology)
Definition A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini.[ PubMed:15574413 ]
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       2
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 Genes
 negative cofactor 2 complex (all annotations which use CV term, excluding "NOT" statements)       2
     part_of | negative cofactor 2 complex       2
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transcription repressor complex_____
nuclear protein-containing complex__|
                                    RNA polymerase II transcription repressor complex
                                     |__negative cofactor 2 complex  2 rec.
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Is a RNA polymerase II transcription repressor complex
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