FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of translation ID (Ontology) GO:0017148 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
Also Known As "down regulation of protein biosynthetic process" ; "down-regulation of protein biosynthetic process" ; "downregulation of protein biosynthetic process" (for all, see Synonyms field below)
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      48
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 negative regulation of translation (all annotations which use CV term, excluding "NOT" statements)       2     48
     involved_in | negative regulation of translation       --      48
Spanning Tree (Parents/Children)
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translation
 |__regulation of translation______________________________
regulation of gene expression                              |
 |__negative regulation of gene expression_________________|
negative regulation of macromolecule biosynthetic process  |
 |__negative regulation of gene expression_________________|
negative regulation of macromolecule metabolic process     |
 |__negative regulation of protein metabolic process_______|
post-transcriptional regulation of gene expression         |
 |__regulation of translation______________________________|
regulation of protein metabolic process                    |
 |__regulation of translation______________________________|
 |__negative regulation of protein metabolic process_______|
                                                           negative regulation of translation  85 rec.
                                                            |__miRNA-mediated gene silencing by inhibition of translation 15 rec.
                                                            |__negative regulation of cytoplasmic translation 5 rec.
                                                            |   |__negative regulation of cytoplasmic translational elongation(+)
                                                            |__negative regulation of mitochondrial translation
                                                            |   |__negative regulation of mitochondrial translational elongation
                                                            |__negative regulation of oskar mRNA translation 9 rec.
                                                            |__negative regulation of translation in response to stress
                                                            |   |__negative regulation of cytoplasmic translational initiation in response to stress
                                                            |   |__negative regulation of translation in response to endoplasmic reticulum stress(+)
                                                            |   |__negative regulation of translation in response to osmotic stress(+)
                                                            |   |__negative regulation of translational initiation in response to starvation
                                                            |   |__regulation of translation in response to oxidative stress(+)
                                                            |   |__sucrose induced translational repression
                                                            |__negative regulation of translational elongation 2 rec.
                                                            |   |__negative regulation of cytoplasmic translational elongation(+)
                                                            |   |__negative regulation of mitochondrial translational elongation
                                                            |   |__negative regulation of selenocysteine incorporation
                                                            |   |__negative regulation of translational frameshifting 1 rec.
                                                            |__negative regulation of translational fidelity
                                                            |__negative regulation of translational initiation 14 rec.
                                                            |   |__negative regulation of cytoplasmic translational initiation(+)
                                                            |   |__negative regulation of formation of translation initiation ternary complex
                                                            |   |__negative regulation of mitochondrial translational initiation
                                                            |   |__negative regulation of translational initiation by iron
                                                            |   |__negative regulation of translational initiation in response to stress(+) 1 rec.
                                                            |__negative regulation of translational termination
                                                            |__ribosome hibernation 1 rec.
                                                            |__siRNA-mediated gene silencing by inhibition of translation
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Is a regulation of translation
negative regulation of gene expression
negative regulation of protein metabolic process
Part of
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Synonyms
  • "down regulation of protein biosynthetic process" EXACT
    "down-regulation of protein biosynthetic process" EXACT
    "downregulation of protein biosynthetic process" EXACT
    "inhibition of protein biosynthetic process" NARROW
    "negative regulation of protein anabolism" EXACT
    "negative regulation of protein biosynthesis" EXACT
    "negative regulation of protein biosynthetic process" EXACT
    "negative regulation of protein formation" EXACT
    "negative regulation of protein synthesis" EXACT
    "protein biosynthesis inhibitor activity" RELATED
    "protein biosynthetic process inhibitor activity" RELATED
Secondary IDs
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