FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
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Term keratan sulfate proteoglycan biosynthetic process ID (Ontology) GO:0018146 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of keratan sulfate proteoglycans, which consist of a core protein linked to a keratan sulfate glycosaminoglycan. The keratan sulfate chain is composed of the repeating disaccharide unit beta-(1,4)-N-acetyl-D-glucosamine-beta-(1,3)-galactose, both of which can be sulfated. Keratan sulfate chains can be covalently linked either to an asparagine residue (N-linked) of the core protein via a high mannose oligasacccharide linker or to serine/threonine residues (O-linked) of the core protein via a core 2 type-linker.[ PubMed:29340594 ]
Also Known As "keratan sulfate anabolism" ; "keratan sulfate biosynthesis" ; "keratan sulfate formation" (for all, see Synonyms field below)
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proteoglycan metabolic process
 |__proteoglycan biosynthetic process_______________
 |__keratan sulfate proteoglycan metabolic process__|
glycoprotein biosynthetic process                   |
 |__proteoglycan biosynthetic process_______________|
                                                    keratan sulfate proteoglycan biosynthetic process
                                                     |__keratan sulfate-I proteoglycan biosynthetic process
                                                     |__keratan sulfate-II proteoglycan biosynthetic process
                                                     |__keratan sulfate-III proteoglycan biosynthetic process
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Is a proteoglycan biosynthetic process
keratan sulfate proteoglycan metabolic process
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Synonyms
  • "keratan sulfate anabolism" EXACT
    "keratan sulfate biosynthesis" EXACT
    "keratan sulfate formation" EXACT
    "keratan sulfate synthesis" EXACT
    "keratan sulphate biosynthesis" EXACT
    "keratan sulphate biosynthetic process" EXACT
Secondary IDs
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Reactome:R-HSA-2022854 "Keratan sulfate biosynthesis"