FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term trypanothione biosynthetic process ID (Ontology) GO:0019342 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress.[ PubMed:9677355 ]
Also Known As "trypanothione anabolism" ; "trypanothione biosynthesis" ; "trypanothione formation" (for all, see Synonyms field below)
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sulfur compound metabolic process
 |__trypanothione metabolic process______________
sulfur compound biosynthetic process             |
 |__glutathione derivative biosynthetic process__|
                                                 trypanothione biosynthetic process
                                                  |__regulation of trypanothione biosynthetic process
                                                      |__negative regulation of trypanothione biosynthetic process
                                                      |__positive regulation of trypanothione biosynthetic process
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Is a trypanothione metabolic process
glutathione derivative biosynthetic process
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Synonyms
  • "trypanothione anabolism" EXACT
    "trypanothione biosynthesis" EXACT
    "trypanothione formation" EXACT
    "trypanothione synthesis" EXACT
Secondary IDs
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MetaCyc:TRYPANOSYN-PWY