FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term protein metabolic process ID (Ontology) GO:0019538 (Gene Ontology)
Definition The chemical reactions and pathways involving a protein. Includes protein modification.
Also Known As "cellular protein metabolic process" ; "cellular protein metabolism" ; "protein metabolic process and modification" (for all, see Synonyms field below)
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Spanning Tree (Parents/Children)
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metabolic process
 |__macromolecule metabolic process__
 |__primary metabolic process________|
                                     protein metabolic process  2753 rec.
                                      |__amyloid fibril formation 1 rec.
                                      |   |__regulation of amyloid fibril formation(+)
                                      |__amyloid precursor protein metabolic process 7 rec.
                                      |   |__amyloid precursor protein biosynthetic process(+) 1 rec.
                                      |   |__amyloid precursor protein catabolic process(+) 5 rec.
                                      |__cytochrome metabolic process
                                      |   |__cytochrome biosynthetic process(+)
                                      |   |__cytochrome c metabolic process(+)
                                      |__ferredoxin metabolic process
                                      |__glycoprotein metabolic process 195 rec.
                                      |   |__elastin metabolic process(+)
                                      |   |__glycoprotein biosynthetic process(+) 177 rec.
                                      |   |__glycoprotein catabolic process(+) 18 rec.
                                      |   |__modulation by host of viral glycoprotein metabolic process(+)
                                      |   |__protein deglycosylation(+) 3 rec.
                                      |   |__proteoglycan metabolic process(+) 40 rec.
                                      |   |__regulation of glycoprotein metabolic process(+) 3 rec.
                                      |__granulocyte macrophage colony-stimulating factor production
                                      |   |__regulation of granulocyte macrophage colony-stimulating factor production(+)
                                      |__hemoglobin metabolic process 1 rec.
                                      |   |__hemoglobin biosynthetic process(+) 1 rec.
                                      |   |__hemoglobin catabolic process
                                      |__hepatocyte growth factor production
                                      |   |__regulation of hepatocyte growth factor production(+)
                                      |__holo-[acyl-carrier-protein] biosynthetic process
                                      |__insulin metabolic process 1 rec.
                                      |   |__insulin catabolic process 1 rec.
                                      |   |__insulin processing
                                      |__lipoprotein metabolic process 3 rec.
                                      |   |__lipoprotein biosynthetic process(+) 1 rec.
                                      |   |__lipoprotein catabolic process(+) 1 rec.
                                      |   |__lipoprotein modification(+)
                                      |   |__regulation of lipoprotein metabolic process(+)
                                      |__lymphotoxin A production
                                      |   |__regulation of lymphotoxin A production(+)
                                      |__Notch receptor processing 16 rec.
                                      |   |__Notch receptor processing, ligand-dependent 4 rec.
                                      |   |__Notch receptor processing, ligand-independent
                                      |__prosthetic group metabolic process 10 rec.
                                      |   |__molybdopterin cofactor metabolic process(+) 10 rec.
                                      |   |__prosthetic group biosynthetic process
                                      |   |__prosthetic group catabolic process
                                      |__protein biosynthetic process 965 rec.
                                      |   |__translation 965 rec.
                                      |__protein catabolic process 443 rec.
                                      |   |__chaperone-mediated autophagy(+)
                                      |   |__epidermal growth factor catabolic process
                                      |   |__glycoprotein catabolic process(+) 18 rec.
                                      |   |__hemoglobin catabolic process
                                      |   |__histone catabolic process
                                      |   |__insulin catabolic process 1 rec.
                                      |   |__lipoprotein catabolic process(+) 1 rec.
                                      |   |__low-density lipoprotein particle receptor catabolic process(+)
                                      |   |__mitochondrial protein catabolic process 3 rec.
                                      |   |__prosthetic group catabolic process
                                      |   |__proteasomal protein catabolic process(+) 314 rec.
                                      |   |__protein catabolic process at synapse(+)
                                      |   |__protein catabolic process in the vacuole(+) 3 rec.
                                      |   |__protein denaturation
                                      |   |__proteolysis involved in protein catabolic process(+) 416 rec.
                                      |   |__PSII associated light-harvesting complex II catabolic process(+)
                                      |   |__regulation of protein catabolic process(+) 91 rec.
                                      |   |__rhodopsin catabolic process
                                      |__protein maturation 351 rec.
                                      |   |__attachment of GPI anchor to protein 7 rec.
                                      |   |__CAAX-box protein maturation(+) 7 rec.
                                      |   |__GPI anchored protein biosynthesis(+) 44 rec.
                                      |   |__N-terminal protein amino acid acetylation(+) 11 rec.
                                      |   |__peptide pheromone maturation 1 rec.
                                      |   |__peptidyl-lysine modification to peptidyl-hypusine 1 rec.
                                      |   |__protein activation cascade(+) 29 rec.
                                      |   |__protein folding(+) 157 rec.
                                      |   |__protein lipoylation 2 rec.
                                      |   |__protein processing(+) 97 rec.
                                      |   |__protein-tetrapyrrole linkage(+)
                                      |   |__regulation of protein maturation(+) 10 rec.
                                      |__protein modification process 493 rec.
                                      |   |__actin modification(+) 2 rec.
                                      |   |__metal incorporation into metallo-molybdopterin complex(+)
                                      |   |__metal incorporation into metallo-sulfur cluster(+)
                                      |   |__N-terminal protein amino acid modification(+) 12 rec.
                                      |   |__nucleic acid-protein covalent cross-linking(+)
                                      |   |__peptide cross-linking(+) 1 rec.
                                      |   |__peptidyl-amino acid modification(+) 62 rec.
                                      |   |__post-translational protein modification(+) 350 rec.
                                      |   |__protein acylation(+) 13 rec.
                                      |   |__protein alkylation(+) 9 rec.
                                      |   |__protein arginylation
                                      |   |__protein carbamoylation
                                      |   |__protein carboxylation(+)
                                      |   |__protein de-ADP-ribosylation(+)
                                      |   |__protein deacylation(+) 1 rec.
                                      |   |__protein dealkylation(+)
                                      |   |__protein deamination(+)
                                      |   |__protein deglutathionylation
                                      |   |__protein deglycation(+)
                                      |   |__protein deglycosylation(+) 3 rec.
                                      |   |__protein dehydration(+)
                                      |   |__protein delipidation
                                      |   |__protein denucleotidylation(+) 1 rec.
                                      |   |__protein dephosphorylation(+) 23 rec.
                                      |   |__protein flavinylation
                                      |   |__protein glutathionylation(+)
                                      |   |__protein hydroxylation(+) 3 rec.
                                      |   |__protein lipidation(+) 1 rec.
                                      |   |__protein nitrosylation(+)
                                      |   |__protein nucleotidylation(+) 1 rec.
                                      |   |__protein oxidation(+)
                                      |   |__protein phosphopantetheinylation(+)
                                      |   |__protein phosphorylation(+) 65 rec.
                                      |   |__protein polyamination
                                      |   |__protein prenylation(+)
                                      |   |__protein sialylation
                                      |   |__protein sulfation(+)
                                      |   |__protein sulfhydration(+)
                                      |   |__protein-coenzyme A linkage(+)
                                      |   |__protein-FAD linkage 2 rec.
                                      |   |__protein-pyridoxal-5-phosphate linkage(+)
                                      |   |__regulation of protein modification process(+) 42 rec.
                                      |__protein repair 1 rec.
                                      |   |__photosystem II repair
                                      |   |__protein deglycation(+)
                                      |__proteolysis 1017 rec.
                                      |   |__membrane protein proteolysis(+) 15 rec.
                                      |   |__protein processing(+) 97 rec.
                                      |   |__proteolysis involved in protein catabolic process(+) 416 rec.
                                      |   |__regulation of proteolysis(+) 121 rec.
                                      |   |__self proteolysis(+) 1 rec.
                                      |__regulation of protein metabolic process 347 rec.
                                      |   |__negative regulation of protein metabolic process(+) 140 rec.
                                      |   |__positive regulation of protein metabolic process(+) 149 rec.
                                      |   |__regulation of amyloid fibril formation(+)
                                      |   |__regulation of amyloid precursor protein catabolic process(+) 1 rec.
                                      |   |__regulation of angiotensin metabolic process
                                      |   |__regulation of glycoprotein metabolic process(+) 3 rec.
                                      |   |__regulation of granulocyte macrophage colony-stimulating factor production(+)
                                      |   |__regulation of hemoglobin biosynthetic process(+)
                                      |   |__regulation of hepatocyte growth factor production(+)
                                      |   |__regulation of lipoprotein metabolic process(+)
                                      |   |__regulation of lymphotoxin A production(+)
                                      |   |__regulation of protein catabolic process(+) 91 rec.
                                      |   |__regulation of protein maturation(+) 10 rec.
                                      |   |__regulation of protein modification process(+) 42 rec.
                                      |   |__regulation of proteolysis(+) 121 rec.
                                      |   |__regulation of translation(+) 169 rec.
                                      |__rhodopsin metabolic process 17 rec.
                                      |   |__rhodopsin biosynthetic process 15 rec.
                                      |__translation 965 rec.
                                          |__cytoplasmic translation(+) 210 rec.
                                          |__maintenance of translational fidelity 1 rec.
                                          |__mitochondrial translation(+) 141 rec.
                                          |__plastid translation
                                          |__regulation of translation(+) 169 rec.
                                          |__regulation of translation by machinery localization
                                          |__translation at synapse(+)
                                          |__translational elongation(+) 37 rec.
                                          |__translational initiation(+) 85 rec.
                                          |__translational termination(+) 13 rec.
                                          |__tRNA aminoacylation for protein translation(+) 43 rec.
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Is a macromolecule metabolic process
primary metabolic process
Part of
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Synonyms
  • "cellular protein metabolic process" EXACT
    "cellular protein metabolism" EXACT
    "multicellular organismal protein metabolic process" NARROW
    "protein metabolic process and modification" EXACT
    "protein metabolism" EXACT
    "protein metabolism and modification" EXACT
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-392499 "Metabolism of proteins"
Wikipedia:Protein_metabolism