FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term cell differentiation ID (Ontology) GO:0030154 (Gene Ontology)
Definition The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.[ ISBN:0198506732 ]
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      72
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 cell differentiation (all annotations which use CV term, excluding "NOT" statements)      72
     involved_in | cell differentiation      72
Spanning Tree (Parents/Children)
Only view relationship:
cellular process_______
developmental process__|
                       cellular developmental process
                        |__cell differentiation  2389 rec.
                            |__anther wall tapetum cell differentiation
                            |__antipodal cell differentiation
                            |__bundle sheath cell differentiation
                            |__cardiocyte differentiation 31 rec.
                            |   |__cardiac endothelial cell differentiation(+)
                            |   |__cardiac fibroblast cell differentiation(+)
                            |   |__cardiac glial cell differentiation(+)
                            |   |__cardiac muscle cell differentiation(+) 6 rec.
                            |   |__cardiac neural crest cell differentiation involved in heart development
                            |   |__cardiac neuron differentiation
                            |   |__cardiac septum cell differentiation(+)
                            |   |__cardiac vascular smooth muscle cell differentiation(+)
                            |   |__cardioblast differentiation(+) 20 rec.
                            |   |__endocardial cushion cell differentiation
                            |   |__heart valve cell differentiation
                            |__cell differentiation in hindbrain
                            |   |__candelabrum cell differentiation
                            |   |__cerebellar basket cell differentiation
                            |   |__cerebellar Golgi cell differentiation
                            |   |__cerebellar granule cell differentiation
                            |   |__cerebellar Purkinje cell differentiation
                            |   |__cerebellar stellate cell differentiation
                            |   |__cerebellar unipolar brush cell differentiation
                            |   |__eurydendroid cell differentiation
                            |   |__Lugaro cell differentiation
                            |__cell differentiation in spinal cord
                            |   |__commissural neuron differentiation in spinal cord
                            |   |__medial motor column neuron differentiation
                            |   |__spinal cord association neuron differentiation
                            |   |__spinal cord motor neuron differentiation(+)
                            |   |__spinal cord oligodendrocyte cell differentiation
                            |   |__spinal cord radial glial cell differentiation
                            |   |__ventral spinal cord interneuron differentiation
                            |__cell differentiation involved in embryonic placenta development
                            |   |__epithelial cell differentiation involved in embryonic placenta development
                            |   |__glycogen cell differentiation involved in embryonic placenta development
                            |   |__spongiotrophoblast differentiation
                            |   |__syncytiotrophoblast cell differentiation involved in labyrinthine layer development
                            |   |__trophoblast giant cell differentiation
                            |__cell differentiation involved in kidney development
                            |   |__cell differentiation involved in mesonephros development(+)
                            |   |__cell differentiation involved in metanephros development(+)
                            |   |__cell differentiation involved in pronephros development(+)
                            |   |__DCT cell differentiation(+)
                            |   |__epithelial cell differentiation involved in kidney development(+)
                            |   |__juxtaglomerulus cell differentiation(+)
                            |   |__kidney interstitial fibroblast differentiation(+)
                            |   |__kidney smooth muscle cell differentiation
                            |   |__mesangial cell differentiation(+)
                            |   |__mesenchymal cell differentiation involved in kidney development(+)
                            |   |__mesenchymal stem cell differentiation involved in nephron morphogenesis(+)
                            |   |__proximal convoluted tubule segment 1 cell differentiation
                            |   |__renal vesicle progenitor cell differentiation
                            |__cell differentiation involved in phenotypic switching
                            |   |__vascular associated smooth muscle cell differentiation involved in phenotypic switching
                            |__cell differentiation involved in salivary gland development
                            |   |__epithelial cell differentiation involved in salivary gland development(+)
                            |   |__mesenchymal cell differentiation involved in salivary gland development
                            |   |__neuron differentiation involved in salivary gland development
                            |__chondroblast differentiation
                            |__chondrocyte differentiation
                            |   |__chondrocyte differentiation involved in endochondral bone morphogenesis(+)
                            |__chorionic trophoblast cell differentiation
                            |__collenchyma cell differentiation
                            |__compound eye cone cell differentiation 15 rec.
                            |__corticotropin hormone secreting cell differentiation
                            |__ectodermal cell differentiation 3 rec.
                            |__embryo sac central cell differentiation
                            |__embryo sac egg cell differentiation
                            |__endodermal cell differentiation 1 rec.
                            |__epithelial cell differentiation 365 rec.
                            |   |__columnar/cuboidal epithelial cell differentiation(+) 6 rec.
                            |   |__corneal epithelial cell differentiation
                            |   |__endothelial cell differentiation(+) 1 rec.
                            |   |__enteroendocrine cell differentiation(+) 8 rec.
                            |   |__epidermal cell differentiation(+) 55 rec.
                            |   |__epithelial cell differentiation involved in embryonic placenta development
                            |   |__epithelial cell differentiation involved in kidney development(+)
                            |   |__epithelial cell differentiation involved in prostate gland development(+)
                            |   |__epithelial cell differentiation involved in salivary gland development(+)
                            |   |__granulosa cell differentiation(+)
                            |   |__hepatoblast differentiation
                            |   |__hepatocyte differentiation
                            |   |__ionocyte differentiation
                            |   |__leading edge cell differentiation(+) 2 rec.
                            |   |__lens fiber cell differentiation
                            |   |__lung epithelial cell differentiation(+)
                            |   |__Malpighian tubule principal cell differentiation
                            |   |__Malpighian tubule stellate cell differentiation 3 rec.
                            |   |__mammary gland epithelial cell differentiation(+)
                            |   |__mesenchymal to epithelial transition(+) 1 rec.
                            |   |__polarized epithelial cell differentiation(+) 7 rec.
                            |   |__Sertoli cell differentiation
                            |   |__ureter epithelial cell differentiation
                            |__fat cell differentiation
                            |   |__beige fat cell differentiation
                            |   |__brown fat cell differentiation
                            |   |__white fat cell differentiation(+)
                            |__foam cell differentiation
                            |   |__macrophage derived foam cell differentiation
                            |   |__smooth muscle derived foam cell differentiation
                            |__follicular dendritic cell differentiation
                            |__generative cell differentiation
                            |__glial cell differentiation 40 rec.
                            |   |__astrocyte differentiation(+)
                            |   |__cardiac glial cell differentiation(+)
                            |   |__glial cell differentiation involved in amphid sensory organ development
                            |   |__lateral line nerve glial cell differentiation(+)
                            |   |__microglia differentiation
                            |   |__oligodendrocyte differentiation(+)
                            |   |__radial glial cell differentiation(+)
                            |   |__Schwann cell differentiation
                            |__hematopoietic progenitor cell differentiation 2 rec.
                            |   |__hematopoietic stem cell differentiation 1 rec.
                            |   |__lymphoid progenitor cell differentiation(+)
                            |   |__myeloid progenitor cell differentiation
                            |__hemocyte differentiation 51 rec.
                            |   |__crystal cell differentiation(+) 25 rec.
                            |   |__embryonic hemocyte differentiation(+) 3 rec.
                            |   |__larval lymph gland hemocyte differentiation(+) 30 rec.
                            |   |__plasmatocyte differentiation(+) 13 rec.
                            |__hepatic stellate cell differentiation
                            |__hypothalamus cell differentiation
                            |   |__hypothalamus gonadotrophin-releasing hormone neuron differentiation
                            |__inner cell mass cell differentiation
                            |__leukocyte differentiation
                            |   |__mononuclear cell differentiation(+)
                            |   |__myeloid leukocyte differentiation(+)
                            |__Leydig cell differentiation
                            |__lung cell differentiation
                            |   |__lung basal cell differentiation
                            |   |__lung epithelial cell differentiation(+)
                            |__luteal cell differentiation
                            |__Malpighian tubule tip cell differentiation 9 rec.
                            |__mesenchymal cell differentiation 10 rec.
                            |   |__cardiac endothelial to mesenchymal transition
                            |   |__epithelial to mesenchymal transition(+) 5 rec.
                            |   |__mesenchymal cell differentiation involved in bone development
                            |   |__mesenchymal cell differentiation involved in lung development
                            |   |__mesenchymal cell differentiation involved in mammary gland development
                            |   |__mesenchymal cell differentiation involved in renal system development(+)
                            |   |__mesenchymal cell differentiation involved in salivary gland development
                            |   |__neural crest cell differentiation(+) 5 rec.
                            |__mesodermal cell differentiation 14 rec.
                            |   |__axial mesodermal cell differentiation
                            |   |__hemangioblast cell differentiation
                            |   |__intermediate mesodermal cell differentiation
                            |   |__lateral mesodermal cell differentiation
                            |   |__paraxial mesodermal cell differentiation
                            |__microgametophyte vegetative cell differentiation
                            |__muscle cell differentiation 127 rec.
                            |   |__smooth muscle cell differentiation(+)
                            |   |__striated muscle cell differentiation(+) 92 rec.
                            |__myeloid cell differentiation
                            |   |__erythrocyte differentiation(+)
                            |   |__megakaryocyte differentiation
                            |   |__myeloid leukocyte differentiation(+)
                            |   |__platelet formation
                            |   |__thrombocyte differentiation
                            |__myoblast differentiation 7 rec.
                            |   |__cardiac muscle cell myoblast differentiation
                            |   |__myoblast differentiation involved in skeletal muscle regeneration
                            |__myofibroblast differentiation
                            |__mystery cell differentiation 1 rec.
                            |__neuroblast differentiation 52 rec.
                            |   |__forebrain neuroblast differentiation
                            |__neurogenesis 1012 rec.
                            |   |__generation of neurons(+) 949 rec.
                            |   |__gliogenesis 95 rec.
                            |__neuromast mantle cell differentiation
                            |   |__anterior lateral line neuromast mantle cell differentiation
                            |   |__posterior lateral line neuromast mantle cell differentiation
                            |__neuromast support cell differentiation
                            |   |__anterior lateral line neuromast support cell differentiation
                            |   |__posterior lateral line neuromast support cell differentiation
                            |__neuron differentiation 876 rec.
                            |   |__central nervous system neuron differentiation(+) 9 rec.
                            |   |__dopaminergic neuron differentiation(+) 2 rec.
                            |   |__GABAergic neuron differentiation(+)
                            |   |__glutamatergic neuron differentiation(+)
                            |   |__hair cell differentiation(+) 49 rec.
                            |   |__mechanoreceptor differentiation(+)
                            |   |__medial motor column neuron differentiation
                            |   |__neuroendocrine cell differentiation(+) 6 rec.
                            |   |__neuron differentiation involved in amphid sensory organ development
                            |   |__neuron differentiation involved in salivary gland development
                            |   |__noradrenergic neuron differentiation(+)
                            |   |__peripheral nervous system neuron differentiation(+) 10 rec.
                            |   |__photoreceptor cell differentiation(+) 246 rec.
                            |__notochord cell differentiation
                            |__oenocyte differentiation 11 rec.
                            |__oocyte differentiation 192 rec.
                            |   |__germarium-derived oocyte differentiation 33 rec.
                            |__osteoblast differentiation
                            |__pericyte cell differentiation
                            |   |__mesangial cell differentiation(+)
                            |__pigment cell differentiation 4 rec.
                            |   |__compound eye pigment cell differentiation
                            |   |__cyanophore differentiation
                            |   |__erythrophore differentiation
                            |   |__iridophore differentiation
                            |   |__leucophore differentiation
                            |   |__melanocyte differentiation(+) 1 rec.
                            |   |__xanthophore differentiation
                            |__pigment cell precursor differentiation
                            |__plant endodermal cell differentiation
                            |__plant epidermal cell differentiation
                            |   |__guard cell differentiation
                            |   |__guard mother cell differentiation
                            |   |__root epidermal cell differentiation(+)
                            |   |__sepal giant cell differentiation
                            |   |__socket cell differentiation
                            |__plant parenchymal cell differentiation
                            |   |__companion cell differentiation
                            |__pollen sperm cell differentiation
                            |__prolactin secreting cell differentiation
                            |__renal filtration cell differentiation 13 rec.
                            |   |__nephrocyte differentiation(+) 13 rec.
                            |   |__podocyte differentiation(+)
                            |__rhombomere cell differentiation
                            |__sclerenchyma cell differentiation
                            |__sieve element differentiation
                            |   |__sieve cell differentiation
                            |__skeletal muscle cell differentiation
                            |   |__skeletal muscle fiber differentiation(+)
                            |   |__skeletal muscle satellite cell differentiation
                            |__somatotropin secreting cell differentiation
                            |__sorocarp spore cell differentiation
                            |__sorocarp stalk cell differentiation
                            |__spermatid differentiation 150 rec.
                            |__sporocyte differentiation
                            |   |__megasporocyte differentiation
                            |   |__microsporocyte differentiation
                            |__stem cell differentiation 53 rec.
                            |   |__angioblast cell differentiation
                            |   |__cardioblast differentiation(+) 20 rec.
                            |   |__hematopoietic stem cell differentiation 1 rec.
                            |   |__hepatoblast differentiation
                            |   |__limb basal epidermal cell differentiation
                            |   |__mesenchymal stem cell differentiation(+)
                            |   |__neural crest cell differentiation(+) 5 rec.
                            |   |__respiratory basal cell differentiation
                            |   |__squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
                            |__synergid differentiation
                            |__tendon cell differentiation
                            |__tracheary element differentiation
                            |   |__xylem vessel member cell differentiation
                            |__transdifferentiation
                            |__trichome differentiation
                            |   |__seed trichome differentiation
                            |__trophectodermal cell differentiation
                            |__vasculogenesis
                                |__central nervous system vasculogenesis
                                |__vasculogenesis involved in coronary vascular morphogenesis
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a cellular developmental process
Part of
hide Synonyms & Secondary IDs
Synonyms
Secondary IDs
hide External Crossreferences & Linkouts
Wikipedia:Cellular_differentiation