FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term B cell differentiation ID (Ontology) GO:0030183 (Gene Ontology)
Definition The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
Also Known As "B lymphocyte differentiation" ; "B-cell differentiation" ; "B-lymphocyte differentiation"
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lymphocyte activation
 |__lymphocyte differentiation____
 |__B cell activation_____________|
mononuclear cell differentiation  |
 |__lymphocyte differentiation____|
                                  B cell differentiation
                                   |__B cell lineage commitment
                                   |   |__B-1 B cell lineage commitment
                                   |__B cell selection
                                   |   |__B cell negative selection(+)
                                   |   |__B cell positive selection(+)
                                   |   |__central B cell selection(+)
                                   |   |__peripheral B cell selection(+)
                                   |__immature B cell differentiation
                                   |   |__pre-B cell differentiation(+)
                                   |   |__transitional stage B cell differentiation(+)
                                   |__mature B cell differentiation
                                   |   |__B-1 B cell differentiation(+)
                                   |   |__mature B cell differentiation involved in immune response(+)
                                   |__regulation of B cell differentiation
                                       |__negative regulation of B cell differentiation(+)
                                       |__positive regulation of B cell differentiation(+)
                                       |__regulation of B-1 B cell differentiation(+)
                                       |__regulation of central B cell anergy(+)
                                       |__regulation of central B cell deletion(+)
                                       |__regulation of plasma cell differentiation(+)
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Is a lymphocyte differentiation
B cell activation
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Synonyms
  • "B cell development" RELATED
    "B lymphocyte differentiation" EXACT
    "B-cell differentiation" EXACT
    "B-lymphocyte differentiation" EXACT
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