FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term pyrrolysine incorporation ID (Ontology) GO:0030631 (Gene Ontology)
Definition The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases.[ PubMed:11435424 PubMed:17204561 ]
Also Known As "lysine methylamine methyltransferase cofactor adduct incorporation" ; "monomethylamine methyltransferase cofactor lysine adduct incorporation"
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translational elongation___
regulation of translation__|
                           translational readthrough
                            |__pyrrolysine incorporation
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Synonyms
  • "lysine methylamine methyltransferase cofactor adduct incorporation" EXACT
    "monomethylamine methyltransferase cofactor lysine adduct incorporation" EXACT
Secondary IDs
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RESID:AA0321