FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term epithelial cell differentiation ID (Ontology) GO:0030855 (Gene Ontology)
Definition The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.[ PubMed:11839751 ]
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       7
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 epithelial cell differentiation (all annotations which use CV term, excluding "NOT" statements)       7
     involved_in | epithelial cell differentiation       7
Spanning Tree (Parents/Children)
Only view relationship:
tissue development
 |__epithelium development______
cellular developmental process  |
 |__cell differentiation________|
                                epithelial cell differentiation  365 rec.
                                 |__columnar/cuboidal epithelial cell differentiation 6 rec.
                                 |   |__ameloblast differentiation
                                 |   |__columnar/cuboidal epithelial cell development(+)
                                 |   |__glandular epithelial cell differentiation(+)
                                 |   |__intestinal epithelial cell differentiation(+)
                                 |   |__multi-ciliated epithelial cell differentiation(+)
                                 |   |__neuroepithelial cell differentiation(+) 6 rec.
                                 |__corneal epithelial cell differentiation
                                 |__endothelial cell differentiation 1 rec.
                                 |   |__blood vessel endothelial cell differentiation(+)
                                 |   |__cardiac endothelial cell differentiation(+)
                                 |   |__endothelial cell development(+) 1 rec.
                                 |   |__endothelial cell fate commitment(+)
                                 |   |__lymphatic endothelial cell differentiation(+)
                                 |   |__regulation of endothelial cell differentiation(+)
                                 |__enteroendocrine cell differentiation 8 rec.
                                 |   |__pancreatic A cell differentiation(+)
                                 |   |__pancreatic D cell differentiation(+)
                                 |   |__pancreatic epsilon cell differentiation(+)
                                 |   |__pancreatic PP cell differentiation(+)
                                 |   |__stomach neuroendocrine cell differentiation(+)
                                 |   |__type B pancreatic cell differentiation(+)
                                 |__epidermal cell differentiation 55 rec.
                                 |   |__epidermal cell fate specification(+) 2 rec.
                                 |   |__hair cell differentiation(+) 49 rec.
                                 |   |__keratinocyte differentiation(+)
                                 |   |__limb basal epidermal cell differentiation(+)
                                 |   |__regulation of epidermal cell differentiation(+) 1 rec.
                                 |   |__sebaceous gland cell differentiation(+)
                                 |__epithelial cell development 308 rec.
                                 |   |__columnar/cuboidal epithelial cell development(+)
                                 |   |__endothelial cell development(+) 1 rec.
                                 |   |__epithelial cell maturation(+)
                                 |   |__epithelial cell morphogenesis(+) 35 rec.
                                 |   |__follicle cell of egg chamber development(+) 277 rec.
                                 |   |__glomerular epithelial cell development(+)
                                 |   |__glomerular epithelial cell fate commitment(+)
                                 |   |__glomerular mesangial cell development(+)
                                 |   |__granulosa cell development
                                 |   |__keratinocyte development(+)
                                 |   |__lens fiber cell development(+)
                                 |   |__pancreatic A cell development
                                 |   |__pancreatic E cell development
                                 |   |__pancreatic PP cell development
                                 |   |__Sertoli cell development(+)
                                 |   |__type B pancreatic cell development(+)
                                 |__epithelial cell differentiation involved in embryonic placenta development
                                 |   |__epithelial cell morphogenesis involved in placental branching
                                 |__epithelial cell differentiation involved in kidney development
                                 |   |__glomerular epithelial cell differentiation(+)
                                 |   |__glomerular mesangial cell differentiation(+)
                                 |   |__mesenchymal to epithelial transition involved in mesonephros morphogenesis(+)
                                 |   |__mesenchymal to epithelial transition involved in metanephros morphogenesis(+)
                                 |   |__mesenchymal to epithelial transition involved in renal vesicle formation(+)
                                 |   |__nephron tubule epithelial cell differentiation(+)
                                 |   |__regulation of epithelial cell differentiation involved in kidney development(+)
                                 |__epithelial cell differentiation involved in prostate gland development
                                 |   |__epithelial cell maturation involved in prostate gland development
                                 |   |__neuroendocrine cell differentiation involved in prostate gland acinus development
                                 |   |__secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
                                 |   |__squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
                                 |__epithelial cell differentiation involved in salivary gland development
                                 |   |__acinar cell differentiation involved in salivary gland development
                                 |   |__epithelial cell maturation involved in salivary gland development
                                 |__epithelial cell fate commitment
                                 |   |__endothelial cell fate commitment(+)
                                 |   |__glomerular parietal epithelial cell fate commitment(+)
                                 |   |__granulosa cell fate commitment
                                 |   |__leading edge cell fate commitment(+)
                                 |   |__pancreatic A cell fate commitment
                                 |   |__pancreatic D cell fate commitment
                                 |   |__pancreatic PP cell fate commitment
                                 |   |__podocyte cell fate commitment(+)
                                 |   |__Sertoli cell fate commitment
                                 |   |__type B pancreatic cell fate commitment
                                 |__granulosa cell differentiation
                                 |   |__cumulus cell differentiation(+)
                                 |   |__granulosa cell development
                                 |   |__granulosa cell fate commitment
                                 |__hepatoblast differentiation
                                 |__hepatocyte differentiation
                                 |   |__regulation of hepatocyte differentiation(+)
                                 |__ionocyte differentiation
                                 |__leading edge cell differentiation 2 rec.
                                 |   |__dorsal closure, leading edge cell differentiation(+) 2 rec.
                                 |   |__leading edge cell fate commitment(+)
                                 |__lens fiber cell differentiation
                                 |   |__lens fiber cell development(+)
                                 |   |__lens fiber cell fate commitment
                                 |   |__regulation of lens fiber cell differentiation(+)
                                 |__lung epithelial cell differentiation
                                 |   |__club cell differentiation
                                 |   |__lung ciliated cell differentiation(+)
                                 |   |__lung secretory cell differentiation(+)
                                 |   |__type I pneumocyte differentiation
                                 |__Malpighian tubule principal cell differentiation
                                 |__Malpighian tubule stellate cell differentiation 3 rec.
                                 |__mammary gland epithelial cell differentiation
                                 |   |__epithelial cell differentiation involved in mammary gland alveolus development
                                 |   |__epithelial cell differentiation involved in mammary gland bud morphogenesis(+)
                                 |   |__epithelial cell differentiation involved in mammary gland cord morphogenesis
                                 |__mesenchymal to epithelial transition 1 rec.
                                 |   |__mesenchymal to epithelial transition involved in mesonephros morphogenesis(+)
                                 |   |__mesenchymal to epithelial transition involved in metanephros morphogenesis(+)
                                 |   |__mesenchymal to epithelial transition involved in renal vesicle formation(+)
                                 |__polarized epithelial cell differentiation 7 rec.
                                 |   |__establishment of epithelial cell apical/basal polarity(+) 6 rec.
                                 |   |__regulation of polarized epithelial cell differentiation(+) 2 rec.
                                 |__regulation of epithelial cell differentiation 4 rec.
                                 |   |__negative regulation of epithelial cell differentiation(+)
                                 |   |__positive regulation of epithelial cell differentiation(+) 1 rec.
                                 |   |__regulation of cumulus cell differentiation(+)
                                 |   |__regulation of endothelial cell differentiation(+)
                                 |   |__regulation of epidermal cell differentiation(+) 1 rec.
                                 |   |__regulation of epithelial cell differentiation involved in kidney development(+)
                                 |   |__regulation of hepatocyte differentiation(+)
                                 |   |__regulation of intestinal epithelial cell development(+)
                                 |   |__regulation of lens fiber cell differentiation(+)
                                 |   |__regulation of lung ciliated cell differentiation(+)
                                 |   |__regulation of lung goblet cell differentiation(+)
                                 |   |__regulation of odontoblast differentiation(+)
                                 |   |__regulation of pancreatic A cell differentiation(+)
                                 |   |__regulation of polarized epithelial cell differentiation(+) 2 rec.
                                 |   |__regulation of stomach neuroendocrine cell differentiation(+)
                                 |__Sertoli cell differentiation
                                 |   |__Sertoli cell development(+)
                                 |   |__Sertoli cell fate commitment
                                 |__ureter epithelial cell differentiation
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Is a cell differentiation
Part of epithelium development
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