FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term endoplasmic reticulum unfolded protein response ID (Ontology) GO:0030968 (Gene Ontology)
Definition The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.[ PubMed:12042763 ]
Also Known As "ER unfolded protein response" ; "erUPR"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      18
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 Genes
 endoplasmic reticulum unfolded protein response (all annotations which use CV term, excluding "NOT" statements)      18
     involved_in | endoplasmic reticulum unfolded protein response      18
Spanning Tree (Parents/Children)
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signal transduction
 |__intracellular signal transduction_________
cellular response to stress                   |
 |__response to endoplasmic reticulum stress__|
                                              endoplasmic reticulum unfolded protein response  24 rec.
                                               |__ATF6-mediated unfolded protein response
                                               |__IRE1-mediated unfolded protein response 4 rec.
                                               |__PERK-mediated unfolded protein response 2 rec.
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Is a response to endoplasmic reticulum stress
intracellular signal transduction
Part of cellular response to unfolded protein
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Synonyms
  • "ER unfolded protein response" EXACT
    "erUPR" EXACT
    "SREBP-mediated signalling pathway" RELATED
Secondary IDs
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Reactome:R-HSA-381119 "Unfolded Protein Response (UPR)"