FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term regulatory ncRNA-mediated gene silencing ID (Ontology) GO:0031047 (Gene Ontology)
Definition A process in which an regulatory non-coding RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.[ PubMed:15020054 ]
Also Known As "RNA-dependent gene silencing"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       8
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 regulatory ncRNA-mediated gene silencing (all annotations which use CV term, excluding "NOT" statements)       8
     involved_in | regulatory ncRNA-mediated gene silencing       8
Spanning Tree (Parents/Children)
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regulation of gene expression______________________________
negative regulation of macromolecule biosynthetic process__|
                                                           negative regulation of gene expression
                                                            |__regulatory ncRNA-mediated gene silencing  263 rec.
                                                                |__co-transcriptional gene silencing by RNA interference machinery
                                                                |__regulation of gene silencing by regulatory ncRNA 17 rec.
                                                                |   |__negative regulation of gene silencing by regulatory ncRNA(+) 10 rec.
                                                                |   |__regulation of post-transcriptional gene silencing by regulatory ncRNA(+) 12 rec.
                                                                |   |__regulation of regulatory ncRNA processing(+) 7 rec.
                                                                |   |__regulation of regulatory ncRNA-mediated heterochromatin formation(+) 1 rec.
                                                                |__regulatory ncRNA processing 50 rec.
                                                                |   |__miRNA processing(+) 13 rec.
                                                                |   |__piRNA processing(+) 32 rec.
                                                                |   |__regulation of regulatory ncRNA processing(+) 7 rec.
                                                                |   |__regulatory ncRNA 3'-end processing(+) 1 rec.
                                                                |   |__siRNA processing(+) 13 rec.
                                                                |   |__tRNA-derived regulatory ncRNA processing
                                                                |__regulatory ncRNA-mediated heterochromatin formation 31 rec.
                                                                |   |__piRNA-mediated heterochromatin formation(+) 20 rec.
                                                                |   |__regulation of regulatory ncRNA-mediated heterochromatin formation(+) 1 rec.
                                                                |   |__siRNA-mediated heterochromatin formation(+) 6 rec.
                                                                |__regulatory ncRNA-mediated post-transcriptional gene silencing 204 rec.
                                                                |   |__lncRNA-mediated post-transcriptional gene silencing 1 rec.
                                                                |   |__lsiRNA processing
                                                                |   |__miRNA-mediated post-transcriptional gene silencing(+) 167 rec.
                                                                |   |__piRNA-mediated gene silencing by mRNA destabilization(+) 12 rec.
                                                                |   |__regulation of post-transcriptional gene silencing by regulatory ncRNA(+) 12 rec.
                                                                |   |__RNAi-mediated antiviral immune response(+) 5 rec.
                                                                |   |__siRNA-mediated post-transcriptional gene silencing(+) 1 rec.
                                                                |   |__sRNA-mediated post-transcriptional gene silencing
                                                                |   |__transitive RNA interference(+)
                                                                |__RISC complex assembly 15 rec.
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Is a negative regulation of gene expression
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Synonyms
  • "gene silencing by RNA" RELATED
    "RNA-dependent gene silencing" EXACT
    "RNA-mediated gene silencing" RELATED
Secondary IDs
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Reactome:R-HSA-211000 "Gene Silencing by RNA"