FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term anaphase-promoting complex-dependent catabolic process ID (Ontology) GO:0031145 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.[ PubMed:15380083 PubMed:15840442 ]
Also Known As "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" ; "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" ; "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      18
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 anaphase-promoting complex-dependent catabolic process (all annotations which use CV term, excluding "NOT" statements)       1     18
     involved_in | anaphase-promoting complex-dependent catabolic process       --      18
Spanning Tree (Parents/Children)
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ubiquitin-dependent protein catabolic process__
proteasomal protein catabolic process__________|
                                               proteasome-mediated ubiquitin-dependent protein catabolic process
                                                |__anaphase-promoting complex-dependent catabolic process  19 rec.
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Is a proteasome-mediated ubiquitin-dependent protein catabolic process
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Synonyms
  • "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT
    "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT
    "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT
    "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT
    "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT
    "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT
    "cyclin breakdown" NARROW
    "cyclin catabolic process" NARROW
    "cyclin catabolism" NARROW
    "cyclin degradation" NARROW
    "degradation of cyclin" NARROW
    "negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation" NARROW
Secondary IDs
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Reactome:R-HSA-174048 "APC/C:Cdc20 mediated degradation of Cyclin B"
Reactome:R-HSA-174143 "APC/C-mediated degradation of cell cycle proteins"
Reactome:R-HSA-174154 "APC/C:Cdc20 mediated degradation of Securin"
Reactome:R-HSA-174184 "Cdc20:Phospho-APC/C mediated degradation of Cyclin A"