FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term T cell costimulation ID (Ontology) GO:0031295 (Gene Ontology)
Definition The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.[ ISBN:0781735149 ]
Also Known As "T cell co-stimulation" ; "T lymphocyte costimulation" ; "T-cell co-stimulation" (for all, see Synonyms field below)
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Spanning Tree (Parents/Children)
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immune system process
 |__lymphocyte costimulation_________________________
regulation of T cell activation                      |
 |__positive regulation of T cell activation_________|
positive regulation of lymphocyte activation         |
 |__lymphocyte costimulation_________________________|
 |__positive regulation of T cell activation_________|
positive regulation of leukocyte cell-cell adhesion  |
 |__positive regulation of T cell activation_________|
                                                     T cell costimulation
                                                      |__CD4-positive, alpha-beta T cell costimulation
                                                      |   |__regulation of CD4-positive, alpha-beta T cell costimulation(+)
                                                      |__regulation of T cell costimulation
                                                          |__negative regulation of T cell costimulation(+)
                                                          |__positive regulation of T cell costimulation(+)
                                                          |__regulation of CD4-positive, alpha-beta T cell costimulation(+)
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Is a lymphocyte costimulation
positive regulation of T cell activation
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Synonyms
  • "T cell co-stimulation" EXACT
    "T lymphocyte costimulation" EXACT
    "T-cell co-stimulation" EXACT
    "T-cell costimulation" EXACT
    "T-lymphocyte costimulation" EXACT
Secondary IDs
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Reactome:R-HSA-388841 "Costimulation by the CD28 family"