FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term cullin-RING ubiquitin ligase complex ID (Ontology) GO:0031461 (Gene Ontology)
Definition Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.[ PubMed:15571813 PubMed:15688063 ]
Also Known As "CRL complex" ; "cullin complex"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       9
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 cullin-RING ubiquitin ligase complex (all annotations which use CV term, excluding "NOT" statements)       2      9
     part_of | cullin-RING ubiquitin ligase complex       --       9
Spanning Tree (Parents/Children)
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intracellular protein-containing complex__
transferase complex_______________________|
                                          ubiquitin ligase complex
                                           |__cullin-RING ubiquitin ligase complex  131 rec.
                                               |__anaphase-promoting complex 19 rec.
                                               |__Cul2-RING ubiquitin ligase complex 9 rec.
                                               |__Cul3-RING ubiquitin ligase complex 20 rec.
                                               |__Cul4-RING E3 ubiquitin ligase complex 14 rec.
                                               |   |__CLRC complex
                                               |   |__Cul4A-RING E3 ubiquitin ligase complex 1 rec.
                                               |   |__Cul4B-RING E3 ubiquitin ligase complex
                                               |__Cul5-RING ubiquitin ligase complex 3 rec.
                                               |__Cul7-RING ubiquitin ligase complex
                                               |__Cul8-RING ubiquitin ligase complex
                                               |__SCF ubiquitin ligase complex 73 rec.
                                                   |__cytoplasmic SCF ubiquitin ligase complex
                                                   |__nuclear SCF ubiquitin ligase complex
                                                   |__SCF-Cdc4 ubiquitin ligase complex
                                                   |__SCF-Ctf13 ubiquitin ligase complex
                                                   |__SCF-Das1 ubiquitin ligase complex
                                                   |__SCF-Dia2/Pof3 ubiquitin ligase complex
                                                   |__SCF-Grr1/Pof2 ubiquitin ligase complex
                                                   |__SCF-Hrt3/Pof7 ubiquitin ligase complex
                                                   |__SCF-Mdm30 ubiquitin ligase complex
                                                   |__SCF-Met30/Pof1 ubiquitin ligase complex
                                                   |__SCF-Pof5 ubiquitin ligase complex
                                                   |__SCF-Rcy1/Pof6 ubiquitin ligase complex
                                                   |__SCF-Saf1/Pof9 ubiquitin ligase complex
                                                   |__SCF-Skp2 ubiquitin ligase complex
                                                   |__SCF-Ucc1 ubiquitin ligase complex
                                                   |__SCF-Ufo1/Pof10 ubiquitin ligase complex
                                                   |__SCF-YDR131C ubiquitin ligase complex
                                                   |__SCF-YLR352W ubiquitin ligase complex
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Is a ubiquitin ligase complex
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Synonyms
  • "CRL complex" EXACT
    "cullin complex" EXACT
    "cullin-RING ligase" RELATED
Secondary IDs
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