FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term receptor internalization ID (Ontology) GO:0031623 (Gene Ontology)
Definition A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.[ PubMed:15006537 PubMed:19643732 ]
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       7
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 Genes
 receptor internalization (all annotations which use CV term, excluding "NOT" statements)       7
     involved_in | receptor internalization       7
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  endocytosis
   |__receptor-mediated endocytosis
       |__receptor internalization  17 rec.
           |__B cell receptor internalization
           |   |__positive regulation of toll-like receptor 9 signaling pathway by B cell receptor internalization
           |__G protein-coupled receptor internalization 4 rec.
           |   |__prostaglandin receptor internalization
           |__insulin receptor internalization
           |   |__negative regulation of insulin receptor signaling pathway by insulin receptor internalization
           |   |__positive regulation of insulin receptor signaling pathway by insulin receptor internalization
           |__neurotransmitter receptor internalization 1 rec.
           |   |__postsynaptic neurotransmitter receptor internalization 1 rec.
           |__regulation of signal transduction by receptor internalization 1 rec.
           |   |__negative regulation of signal transduction by receptor internalization(+)
           |   |__positive regulation of signal transduction by receptor internalization(+) 1 rec.
           |__Wnt receptor internalization
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