FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term SREBP signaling pathway ID (Ontology) GO:0032933 (Gene Ontology)
Definition The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.[ PubMed:12923525 PubMed:22017871 ]
Also Known As "endoplasmic reticulum to nucleus sterol response pathway" ; "endoplasmic reticulum-nuclear sterol response pathway" ; "ER to nucleus sterol response pathway" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       3
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 SREBP signaling pathway (all annotations which use CV term, excluding "NOT" statements)       1      3
     involved_in | SREBP signaling pathway       --       3
Spanning Tree (Parents/Children)
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response to sterol depletion
 |__cellular response to sterol depletion__
cellular response to stress                |
 |__cellular response to sterol depletion__|
intracellular signal transduction          |
 |__ER-nucleus signaling pathway___________|
                                           SREBP signaling pathway  5 rec.
                                            |__regulation of SREBP signaling pathway 1 rec.
                                                |__negative regulation of SREBP signaling pathway(+)
                                                |__positive regulation of SREBP signaling pathway(+) 1 rec.
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Is a ER-nucleus signaling pathway
cellular response to sterol depletion
Part of
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Synonyms
  • "activation of sterol regulatory element binding protein target gene transcription" NARROW
    "endoplasmic reticulum to nucleus sterol response pathway" EXACT
    "endoplasmic reticulum-nuclear sterol response pathway" EXACT
    "ER to nucleus sterol response pathway" EXACT
    "ER-nuclear sterol response pathway" EXACT
    "positive regulation of sterol regulatory element binding protein target gene transcription" EXACT
    "positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response" EXACT
    "positive regulation of transcription via sterol regulatory element binding" NARROW
    "positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway" NARROW
    "SREBP signalling" EXACT
    "SREBP target gene transcriptional activation" EXACT
    "SREBP-mediated signaling pathway" RELATED
    "SREBP-mediated signalling pathway" EXACT
    "sterol depletion response, SREBP target gene transcriptional activation" EXACT
    "sterol regulatory element binding protein target gene transcriptional activation" BROAD
    "sterol response element binding protein signaling pathway" EXACT
    "stimulation of sterol regulatory element binding protein target gene transcription" NARROW
    "up regulation of sterol regulatory element binding protein target gene transcription" EXACT
    "up-regulation of sterol regulatory element binding protein target gene transcription" EXACT
    "upregulation of sterol regulatory element binding protein target gene transcription" EXACT
Secondary IDs
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