FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term tumor necrosis factor-mediated signaling pathway ID (Ontology) GO:0033209 (Gene Ontology)
Definition The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Also Known As "tumor necrosis factor-mediated signalling pathway"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      14
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 tumor necrosis factor-mediated signaling pathway (all annotations which use CV term, excluding "NOT" statements)       2     14
     involved_in | tumor necrosis factor-mediated signaling pathway       --      14
Spanning Tree (Parents/Children)
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cell surface receptor signaling pathway
 |__cytokine-mediated signaling pathway_________
response to tumor necrosis factor               |
 |__cellular response to tumor necrosis factor__|
cellular response to cytokine stimulus          |
 |__cytokine-mediated signaling pathway_________|
 |__cellular response to tumor necrosis factor__|
                                                tumor necrosis factor-mediated signaling pathway  29 rec.
                                                 |__regulation of tumor necrosis factor-mediated signaling pathway 14 rec.
                                                     |__negative regulation of tumor necrosis factor-mediated signaling pathway 6 rec.
                                                     |__positive regulation of tumor necrosis factor-mediated signaling pathway 8 rec.
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Is a cytokine-mediated signaling pathway
Part of cellular response to tumor necrosis factor
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Synonyms
  • "adipocytokine signaling pathway" RELATED
    "TNF-alpha-mediated signaling pathway" NARROW
    "tumor necrosis factor alpha-mediated signaling pathway" NARROW
    "tumor necrosis factor-mediated signalling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-5668541 "TNFR2 non-canonical NF-kB pathway"
Reactome:R-HSA-75893 "TNF signaling"