FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term eukaryotic 48S preinitiation complex ID (Ontology) GO:0033290 (Gene Ontology)
Definition The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC.[ PubMed:16510876 PubMed:24319994 PubMed:24499181 PubMed:29735639 ]
Also Known As "eukaryotic 48S pre-initiation complex"
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       1
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 eukaryotic 48S preinitiation complex (all annotations which use CV term, excluding "NOT" statements)       1
     part_of | eukaryotic 48S preinitiation complex       1
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cytoplasm__________________
ribonucleoprotein complex__|
                           cytosolic translation preinitiation complex
                            |__eukaryotic 48S preinitiation complex  1 rec.
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Is a cytosolic translation preinitiation complex
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    "eukaryotic 48S pre-initiation complex" EXACT
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