FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term HULC complex ID (Ontology) GO:0033503 (Gene Ontology)
Definition A ubiquitin ligase complex that contains two RING finger proteins, which have ubiquitin ligase activity, in addition to a protein with ubiquitin-conjugating enzyme activity; catalyzes the ubiquitination of histone H2B at lysine 119 (or the equivalent residue). In Schizosaccharomyces the subunits are Rhp6, Shf1, Brl2/Rfp1 and Brl1/Rfp2.[ PubMed:17363370 PubMed:17374714 ]
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       2
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 Genes
 HULC complex (all annotations which use CV term, excluding "NOT" statements)       2
     part_of | HULC complex       2
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chromosome
 |__chromatin_____________________________
cellular anatomical structure             |
 |__chromatin_____________________________|
intracellular protein-containing complex  |
 |__ubiquitin ligase complex______________|
 |__ubiquitin conjugating enzyme complex__|
transferase complex                       |
 |__ubiquitin ligase complex______________|
 |__ubiquitin conjugating enzyme complex__|
                                          HULC complex  2 rec.
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Is a ubiquitin ligase complex
ubiquitin conjugating enzyme complex
Part of chromatin
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