FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term cellular response to stress ID (Ontology) GO:0033554 (Gene Ontology)
Definition Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
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 cellular response to stress (all annotations which use CV term, excluding "NOT" statements)       1
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cellular process
 |__cellular response to stimulus__
response to stimulus               |
 |__response to stress_____________|
 |__cellular response to stimulus__|
                                   cellular response to stress  628 rec.
                                    |__cellular detoxification of nitrogen compound 1 rec.
                                    |__cellular response to actin cytoskeletal stress
                                    |__cellular response to anoxia 2 rec.
                                    |__cellular response to caloric restriction
                                    |__cellular response to cell envelope stress
                                    |__cellular response to chemical stress 43 rec.
                                    |   |__cellular response to boron-containing substance deprivation
                                    |   |__cellular response to hydrostatic pressure
                                    |   |__cellular response to hyperoxia
                                    |   |__cellular response to nitrosative stress(+)
                                    |   |__cellular response to osmotic stress(+) 4 rec.
                                    |   |__cellular response to oxidative stress(+) 38 rec.
                                    |   |__cellular response to sugar-phosphate stress(+)
                                    |   |__cellular stress response to acidic pH
                                    |   |__response to manganese-induced endoplasmic reticulum stress
                                    |__cellular response to cold 5 rec.
                                    |   |__cellular response to freezing
                                    |__cellular response to fluid shear stress 1 rec.
                                    |   |__cellular response to laminar fluid shear stress(+)
                                    |   |__cellular response to oscillatory fluid shear stress(+)
                                    |   |__cellular response to pulsatile fluid shear stress(+) 1 rec.
                                    |   |__vascular endothelial cell response to fluid shear stress(+)
                                    |__cellular response to heat 40 rec.
                                    |   |__cellular heat acclimation 1 rec.
                                    |   |__heat shock-mediated polytene chromosome puffing 9 rec.
                                    |   |__mRNA export from nucleus in response to heat stress(+) 5 rec.
                                    |   |__regulation of cellular response to heat(+)
                                    |__cellular response to hypoxia 33 rec.
                                    |   |__hypoxia-inducible factor-1alpha signaling pathway(+)
                                    |   |__intrinsic apoptotic signaling pathway in response to hypoxia(+)
                                    |   |__regulation of cellular response to hypoxia(+) 3 rec.
                                    |__cellular response to immobilization stress
                                    |__cellular response to isolation stress
                                    |__cellular response to starvation 92 rec.
                                    |   |__aggregation involved in sorocarp development(+)
                                    |   |__cellular response to adenine starvation
                                    |   |__cellular response to amino acid starvation(+) 17 rec.
                                    |   |__cellular response to biotin starvation
                                    |   |__cellular response to boron-containing substance deprivation
                                    |   |__cellular response to calcium ion starvation
                                    |   |__cellular response to copper ion starvation
                                    |   |__cellular response to glucose starvation(+) 3 rec.
                                    |   |__cellular response to inositol starvation
                                    |   |__cellular response to iron ion starvation(+)
                                    |   |__cellular response to magnesium starvation
                                    |   |__cellular response to nitrogen starvation(+) 5 rec.
                                    |   |__cellular response to phosphate starvation(+) 6 rec.
                                    |   |__cellular response to potassium ion starvation
                                    |   |__cellular response to sucrose starvation 1 rec.
                                    |   |__cellular response to sulfate starvation
                                    |   |__cellular response to sulfur starvation
                                    |   |__cellular response to vitamin B1 starvation
                                    |   |__cellular response to zinc ion starvation
                                    |   |__regulation of translational initiation in response to starvation(+)
                                    |   |__stringent response
                                    |__cellular response to sterol depletion 5 rec.
                                    |   |__SREBP signaling pathway(+) 5 rec.
                                    |__cellular response to topologically incorrect protein 40 rec.
                                    |   |__cellular response to misfolded protein(+) 6 rec.
                                    |   |__cellular response to unfolded protein(+) 33 rec.
                                    |__cellular response to water deprivation 1 rec.
                                    |   |__cellular response to desiccation(+) 1 rec.
                                    |   |__trehalose transport in response to water deprivation(+)
                                    |__cellular senescence 3 rec.
                                    |   |__oncogene-induced cell senescence
                                    |   |__regulation of cellular senescence(+) 3 rec.
                                    |   |__stress-induced premature senescence(+)
                                    |__cellular stress response to acid chemical
                                    |__defense response by cell wall thickening
                                    |   |__defense response by callose deposition in cell wall
                                    |__DNA damage response 294 rec.
                                    |   |__broken chromosome clustering
                                    |   |__DNA damage tolerance(+) 17 rec.
                                    |   |__DNA repair(+) 213 rec.
                                    |   |__DNA repair-dependent chromatin remodeling 17 rec.
                                    |   |__intrinsic apoptotic signaling pathway in response to DNA damage(+) 15 rec.
                                    |   |__signal transduction in response to DNA damage(+) 42 rec.
                                    |   |__SOS response
                                    |   |__telomere maintenance in response to DNA damage(+) 4 rec.
                                    |__DNA protection 1 rec.
                                    |__GDF15-GFRAL signaling pathway
                                    |__integrated stress response signaling 2 rec.
                                    |   |__GCN2-mediated signaling
                                    |   |__HRI-mediated signaling
                                    |   |__PERK-mediated unfolded protein response(+) 2 rec.
                                    |   |__PKR/eIFalpha signaling
                                    |__negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
                                    |__neuron projection regeneration 21 rec.
                                    |   |__axon regeneration(+) 18 rec.
                                    |   |__dendrite regeneration 5 rec.
                                    |   |__regulation of neuron projection regeneration(+) 14 rec.
                                    |__plant-type hypersensitive response
                                    |   |__regulation of plant-type hypersensitive response(+)
                                    |__priming of cellular response to stress
                                    |__regulation of cellular response to stress 66 rec.
                                    |   |__negative regulation of cellular response to nitrogen starvation
                                    |   |__negative regulation of GDF15-GFRAL signaling pathway
                                    |   |__priming of cellular response to stress
                                    |   |__regulation of aggregation involved in sorocarp development(+)
                                    |   |__regulation of cellular response to amino acid starvation(+)
                                    |   |__regulation of cellular response to glucose starvation
                                    |   |__regulation of cellular response to heat(+)
                                    |   |__regulation of cellular response to hypoxia(+) 3 rec.
                                    |   |__regulation of cellular response to iron ion starvation(+)
                                    |   |__regulation of cellular response to osmotic stress(+)
                                    |   |__regulation of cellular response to oxidative stress(+) 5 rec.
                                    |   |__regulation of cellular response to phosphate starvation(+) 3 rec.
                                    |   |__regulation of DNA damage checkpoint(+) 2 rec.
                                    |   |__regulation of DNA damage response, signal transduction by p53 class mediator(+) 3 rec.
                                    |   |__regulation of DNA repair(+) 17 rec.
                                    |   |__regulation of eIF2 alpha phosphorylation by dsRNA
                                    |   |__regulation of eIF2 alpha phosphorylation by heme
                                    |   |__regulation of error-prone translesion synthesis(+)
                                    |   |__regulation of induction of conjugation upon nitrogen starvation
                                    |   |__regulation of intrinsic apoptotic signaling pathway in response to DNA damage(+) 3 rec.
                                    |   |__regulation of neuron projection regeneration(+) 14 rec.
                                    |   |__regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway(+)
                                    |   |__regulation of plant-type hypersensitive response(+)
                                    |   |__regulation of response to endoplasmic reticulum stress(+) 11 rec.
                                    |   |__regulation of SREBP signaling pathway(+) 1 rec.
                                    |   |__regulation of stress-activated protein kinase signaling cascade(+) 5 rec.
                                    |   |__regulation of telomere maintenance in response to DNA damage(+)
                                    |__regulation of mRNA stability involved in response to stress
                                    |   |__regulation of mRNA stability involved in response to oxidative stress
                                    |__regulation of translation in response to stress 2 rec.
                                    |   |__negative regulation of translation in response to stress(+)
                                    |   |__positive regulation of translation in response to stress(+)
                                    |   |__regulation of cytoplasmic translation in response to stress(+)
                                    |   |__regulation of translation in response to endoplasmic reticulum stress(+) 2 rec.
                                    |   |__regulation of translation in response to osmotic stress(+)
                                    |   |__regulation of translational initiation in response to stress(+)
                                    |__response to endoplasmic reticulum stress 98 rec.
                                    |   |__endoplasmic reticulum stress-induced pre-emptive quality control
                                    |   |__endoplasmic reticulum unfolded protein response(+) 24 rec.
                                    |   |__ER overload response(+)
                                    |   |__ERAD pathway(+) 46 rec.
                                    |   |__intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(+) 7 rec.
                                    |   |__regulation of response to endoplasmic reticulum stress(+) 11 rec.
                                    |   |__regulation of translation in response to endoplasmic reticulum stress(+) 2 rec.
                                    |   |__response to manganese-induced endoplasmic reticulum stress
                                    |__response to mitochondrial depolarisation
                                    |__stress-activated protein kinase signaling cascade 7 rec.
                                    |   |__regulation of stress-activated protein kinase signaling cascade(+) 5 rec.
                                    |   |__stress-activated MAPK cascade(+) 5 rec.
                                    |__stress-induced homeostatically regulated protein degradation pathway
                                    |__stress-induced mitochondrial fusion
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Reactome:R-HSA-2262752 "Cellular responses to stress"