FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term TSC1-TSC2 complex ID (Ontology) GO:0033596 (Gene Ontology)
Definition A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway.[ PubMed:10585443 PubMed:17121544 PubMed:9580671 ]
Also Known As "tuberin-hamartin complex" ; "tuberous sclerosis complex"
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       3
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 TSC1-TSC2 complex (all annotations which use CV term, excluding "NOT" statements)       1      3
     part_of | TSC1-TSC2 complex       --       3
Spanning Tree (Parents/Children)
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cellular_component
 |__protein-containing complex__
cytoplasm                       |
 |__cytosol_____________________|
cellular anatomical structure   |
 |__cytosol_____________________|
                                TSC1-TSC2 complex  4 rec.
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Is a protein-containing complex
Part of cytosol
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Synonyms
  • "tuberin-hamartin complex" EXACT
    "tuberous sclerosis complex" EXACT
Secondary IDs
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