FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term VCP-NPL4-UFD1 AAA ATPase complex ID (Ontology) GO:0034098 (Gene Ontology)
Definition A multiprotein ATPase complex required for the efficient dislocation of ER-lumenal degradation substrates, and their subsequent proteolysis by the proteasome. In budding yeast, this complex includes Cdc48p, Npl4p and Ufd1p proteins. In mammals, this complex includes a hexamer of VCP/p97 (a cytosolic ATPase) and trimers of each of its cofactors UFD1L and NPL4 (NPLOC4) (e.g. a 6:3:3 stoichiometry).[ PubMed:11813000 PubMed:16179952 ]
Also Known As "p97-Ufd1-Npl4 complex"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       3
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Relevant FlyBase reports
 Genes
 VCP-NPL4-UFD1 AAA ATPase complex (all annotations which use CV term, excluding "NOT" statements)       3
     part_of | VCP-NPL4-UFD1 AAA ATPase complex       3
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endoplasmic reticulum
 |__endoplasmic reticulum protein-containing complex___________
membrane                                                       |
 |__membrane protein complex___________________________________|
organelle membrane                                             |
 |__endoplasmic reticulum membrane_____________________________|
protein-containing complex                                     |
 |__membrane protein complex___________________________________|
 |__endoplasmic reticulum protein-containing complex___________|
nuclear outer membrane-endoplasmic reticulum membrane network  |
 |__endoplasmic reticulum membrane_____________________________|
endoplasmic reticulum subcompartment                           |
 |__endoplasmic reticulum membrane_____________________________|
                                                               VCP-NPL4-UFD1 AAA ATPase complex  3 rec.
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Is a membrane protein complex
endoplasmic reticulum protein-containing complex
Part of endoplasmic reticulum membrane
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Synonyms
  • "Cdc48p-Npl4p-Ufd1p AAA ATPase complex" NARROW
    "p97-Ufd1-Npl4 complex" EXACT[ PubMed:12847084 ]
Secondary IDs
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