FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term response to endoplasmic reticulum stress ID (Ontology) GO:0034976 (Gene Ontology)
Definition Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
Also Known As "cellular response to endoplasmic reticulum stress" ; "ER stress response" ; "response to ER stress"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      38
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 response to endoplasmic reticulum stress (all annotations which use CV term, excluding "NOT" statements)      38
     involved_in | response to endoplasmic reticulum stress      38
Spanning Tree (Parents/Children)
Only view relationship: 
response to stress_____________
cellular response to stimulus__|
                               cellular response to stress
                                |__response to endoplasmic reticulum stress  98 rec.
                                    |__endoplasmic reticulum stress-induced pre-emptive quality control
                                    |__endoplasmic reticulum unfolded protein response 24 rec.
                                    |   |__ATF6-mediated unfolded protein response
                                    |   |__IRE1-mediated unfolded protein response 4 rec.
                                    |   |__PERK-mediated unfolded protein response 2 rec.
                                    |__ER overload response
                                    |   |__detection of endoplasmic reticulum overloading
                                    |   |__positive regulation of autophagy in response to ER overload
                                    |__ERAD pathway 46 rec.
                                    |   |__ubiquitin-dependent glycoprotein ERAD pathway 3 rec.
                                    |__intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 7 rec.
                                    |   |__neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
                                    |__response to manganese-induced endoplasmic reticulum stress
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Is a cellular response to stress
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Synonyms
  • "cellular response to endoplasmic reticulum stress" EXACT
    "ER stress response" EXACT
    "response to ER stress" EXACT
Secondary IDs
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