FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term Ecsit-NDUFAF1 complex ID (Ontology) GO:0034985 (Gene Ontology)
Definition Any large protein complex that contains Ecsit and NDUFAF1, is located in the mitochondrion, and is involved in the assembly of complex I of the oxidative phosphorylation system. In mammalian cells, three complexes of approximately 500, 600, and 850 kDa containing the 45 kDa isoform of Ecsit and NDUFAF1 have been observed.[ PubMed:17344420 ]
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mitochondrion
 |__mitochondrial matrix______________________
 |__mitochondrial protein-containing complex__|
protein-containing complex                    |
 |__mitochondrial protein-containing complex__|
intracellular organelle lumen                 |
 |__mitochondrial matrix______________________|
                                              Ecsit-NDUFAF1 complex
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Is a mitochondrial protein-containing complex
Part of mitochondrial matrix
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