FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term ESC/E(Z) complex ID (Ontology) GO:0035098 (Gene Ontology)
Definition A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.[ PubMed:12408863 PubMed:12408864 PubMed:17107999 PubMed:20064375 PubMed:31123059 PubMed:33232890 ]
Also Known As "Extra Sex Combs/Enhancer of Zeste complex" ; "polycomb repressive complex 2" ; "PRC2 complex"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       5
Genes (FBgn)  GO_CELLULAR_COMPONENT       8
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 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 ESC/E(Z) complex (all annotations which use CV term, excluding "NOT" statements)       2      8
     part_of | ESC/E(Z) complex       --       8
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nucleoplasm
 |__histone methyltransferase complex__
methyltransferase complex              |
 |__histone methyltransferase complex__|
nuclear protein-containing complex     |
 |__PcG protein complex________________|
 |__histone methyltransferase complex__|
                                       ESC/E(Z) complex  10 rec.
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Is a PcG protein complex
histone methyltransferase complex
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Synonyms
  • "Extra Sex Combs/Enhancer of Zeste complex" EXACT
    "polycomb repressive complex 2" EXACT
    "PRC2 complex" EXACT[ PubMed:20064375 ]
Secondary IDs
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