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General Information
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| Term |
hippo signaling |
ID (Ontology) |
GO:0035329 (Gene Ontology) |
| Definition |
An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation.[ PubMed:17318211 PubMed:18328423 PubMed:36347846 ] |
| Also Known As |
"hippo signal transduction" ; "hippo signaling pathway" |
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Links to External Ontologies
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QuickGO data AmiGO data
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Annotations
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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| Data Class | Field | Records |
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| Genes (FBgn) | GO_BIOLOGICAL_PROCESS | 8 |
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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| Full annotation statements | Relevant FlyBase reports |
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| Gene Groups | Genes |
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hippo signaling (all annotations which use CV term, excluding "NOT" statements) | 1 | 8 | involved_in | hippo signaling | -- | 8 |
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Relationships
