FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term non-canonical Wnt signaling pathway ID (Ontology) GO:0035567 (Gene Ontology)
Definition A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via effectors other than beta-catenin.[ PubMed:37804416 ]
Also Known As "beta-catenin-independent Wnt receptor signaling pathway" ; "non-canonical Wnt receptor signaling pathway" ; "non-canonical Wnt receptor signalling pathway" (for all, see Synonyms field below)
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       7
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 non-canonical Wnt signaling pathway (all annotations which use CV term, excluding "NOT" statements)       7
     involved_in | non-canonical Wnt signaling pathway       7
Spanning Tree (Parents/Children)
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  cell surface receptor signaling pathway
   |__Wnt signaling pathway
       |__non-canonical Wnt signaling pathway  9 rec.
           |__Frizzled Nuclear Import pathway 1 rec.
           |   |__regulation of Frizzled Nuclear Import pathway(+)
           |__non-canonical Wnt signaling pathway involved in heart development
           |   |__planar cell polarity pathway involved in cardiac muscle cell fate commitment
           |__regulation of non-canonical Wnt signaling pathway 1 rec.
           |   |__negative regulation of non-canonical Wnt signaling pathway(+)
           |   |__positive regulation of non-canonical Wnt signaling pathway(+)
           |   |__regulation of Frizzled Nuclear Import pathway(+)
           |   |__regulation of Wnt signaling pathway, calcium modulating pathway(+)
           |   |__regulation of Wnt signaling pathway, planar cell polarity pathway(+)
           |__Wnt signaling pathway, calcium modulating pathway
           |   |__regulation of Wnt signaling pathway, calcium modulating pathway(+)
           |__Wnt signaling pathway, planar cell polarity pathway 1 rec.
           |   |__planar cell polarity pathway involved in cardiac muscle cell fate commitment
           |   |__regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division
           |   |__regulation of Wnt signaling pathway, planar cell polarity pathway(+)
           |__Wnt signaling pathway, regulating spindle positioning
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Is a Wnt signaling pathway
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Synonyms
  • "beta-catenin-independent Wnt receptor signaling pathway" EXACT
    "non-canonical Wnt receptor signaling pathway" EXACT
    "non-canonical Wnt receptor signalling pathway" EXACT
    "non-canonical Wnt-activated signaling pathway" EXACT
Secondary IDs
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Reactome:R-HSA-3858494 "Beta-catenin independent WNT signaling"