General Information
Term	sequestering of BMP in extracellular matrix	ID (Ontology)	GO:0035582 (Gene Ontology)
Definition	Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.[ PubMed:20855508 ]
Also Known As	"BMP sequestration in the ECM" ; "negative regulation of BMP signaling pathway by extracellular sequestering of BMP" ; "negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP" (for all, see Synonyms field below)
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Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available

General Information

Term

sequestering of BMP in extracellular matrix

ID (Ontology)

GO:0035582 (Gene Ontology)

Definition

Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.[ PubMed:20855508 ]

Also Known As

"BMP sequestration in the ECM" ; "negative regulation of BMP signaling pathway by extracellular sequestering of BMP" ; "negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

regulation of BMP signaling pathway
 |__negative regulation of BMP signaling pathway_________________________________________________
maintenance of protein location                                                                  |
 |__maintenance of protein location in extracellular region______________________________________|
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway  |
 |__negative regulation of BMP signaling pathway_________________________________________________|
negative regulation of cellular response to growth factor stimulus                               |
 |__negative regulation of BMP signaling pathway_________________________________________________|
extracellular negative regulation of signal transduction                                         |
 |__sequestering of extracellular ligand from receptor___________________________________________|
                                                                                         sequestering of BMP in extracellular matrix

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Is a	negative regulation of BMP signaling pathway sequestering of extracellular ligand from receptor maintenance of protein location in extracellular region
Part of
Synonyms & Secondary IDs
Synonyms
	"BMP sequestration in the ECM" EXACT[ PubMed:20855508 ] "negative regulation of BMP signaling pathway by extracellular sequestering of BMP" EXACT "negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP" EXACT "negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein" EXACT
Secondary IDs

External Crossreferences & Linkouts

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Parents/Children
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Relationships

Is a

negative regulation of BMP signaling pathway
sequestering of extracellular ligand from receptor
maintenance of protein location in extracellular region

Part of

Synonyms & Secondary IDs

Synonyms

"BMP sequestration in the ECM" EXACT[ PubMed:20855508 ]
"negative regulation of BMP signaling pathway by extracellular sequestering of BMP" EXACT
"negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP" EXACT
"negative regulation of bone morphogenetic protein signaling pathway by extracellular matrix sequestering of bone morphogenetic protein" EXACT

Secondary IDs

External Crossreferences & Linkouts