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| Term | sequestering of TGFbeta in extracellular matrix | ID (Ontology) | GO:0035583 (Gene Ontology) |
| Definition | Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.[ PubMed:12482908 PubMed:20855508 ] | ||
| Also Known As | "negative regulation of transforming growth factor beta receptor signaling pathway by extracellular matrix sequestering of TGFbeta" ; "negative regulation of transforming growth factor beta receptor signalling pathway by extracellular matrix sequestering of TGFbeta" ; "sequestering of TGFbeta large latency complex in extracellular matrix" (for all, see Synonyms field below) | ||
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regulation of transforming growth factor beta receptor signaling pathway |__negative regulation of transforming growth factor beta receptor signaling pathway____________ maintenance of protein location | |__maintenance of protein location in extracellular region______________________________________| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | |__negative regulation of transforming growth factor beta receptor signaling pathway____________| extracellular negative regulation of signal transduction | |__sequestering of extracellular ligand from receptor___________________________________________| sequestering of TGFbeta in extracellular matrix |
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negative regulation of transforming growth factor beta receptor signaling pathway sequestering of extracellular ligand from receptor maintenance of protein location in extracellular region |
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