FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term transcription factor AP-1 complex ID (Ontology) GO:0035976 (Gene Ontology)
Definition A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.[ PubMed:20060892 PubMed:9069263 ]
Also Known As "Activating protein 1 complex" ; "AP-1 complex" ; "AP1 complex" (for all, see Synonyms field below)
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Data Class Field Records
Genes (FBgn)  GO_CELLULAR_COMPONENT       2
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 Genes
 transcription factor AP-1 complex (all annotations which use CV term, excluding "NOT" statements)       2
     part_of | transcription factor AP-1 complex       2
Spanning Tree (Parents/Children)
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transcription regulator complex_____
nuclear protein-containing complex__|
                                    RNA polymerase II transcription regulator complex
                                     |__transcription factor AP-1 complex  2 rec.
                                         |__atf1-pcr1 complex
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Is a RNA polymerase II transcription regulator complex
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Synonyms
  • "Activating protein 1 complex" EXACT
    "AP-1 complex" EXACT
    "AP1 complex" EXACT
    "transcription factor AP1 complex" EXACT
Secondary IDs
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