FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term protein modification process ID (Ontology) GO:0036211 (Gene Ontology)
Definition The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
Also Known As "cellular protein modification process" ; "process resulting in protein modification" ; "protein modification"
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       1
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 protein modification process (all annotations which use CV term, excluding "NOT" statements)       1
     involved_in | protein modification process       1
Spanning Tree (Parents/Children)
Only view relationship:
macromolecule metabolic process
 |__protein metabolic process___
 |__macromolecule modification__|
primary metabolic process       |
 |__protein metabolic process___|
                                protein modification process  493 rec.
                                 |__actin modification 2 rec.
                                 |   |__actin ubiquitination
                                 |__metal incorporation into metallo-molybdopterin complex
                                 |   |__molybdenum incorporation into molybdenum-molybdopterin complex
                                 |   |__tungsten incorporation into tungsten-molybdopterin complex
                                 |__metal incorporation into metallo-sulfur cluster
                                 |   |__copper incorporation into metallo-sulfur cluster(+)
                                 |   |__iron incorporation into metallo-sulfur cluster
                                 |   |__molybdenum incorporation into metallo-sulfur cluster(+)
                                 |   |__nickel incorporation into metallo-sulfur cluster(+)
                                 |__N-terminal protein amino acid modification 12 rec.
                                 |   |__N-terminal protein amino acid acetylation(+) 11 rec.
                                 |   |__N-terminal protein amino acid carbamoylation
                                 |   |__N-terminal protein amino acid carboxylation
                                 |   |__N-terminal protein amino acid deamination(+)
                                 |   |__N-terminal protein amino acid methylation(+)
                                 |   |__N-terminal protein formylation
                                 |   |__N-terminal protein lipidation(+) 1 rec.
                                 |__nucleic acid-protein covalent cross-linking
                                 |   |__RNA-protein covalent cross-linking(+)
                                 |__peptide cross-linking 1 rec.
                                 |   |__isopeptide cross-linking(+)
                                 |   |__peptide cross-linking via L-cystine
                                 |__peptidyl-amino acid modification 62 rec.
                                 |   |__peptidyl-alanine modification(+)
                                 |   |__peptidyl-arginine modification(+) 3 rec.
                                 |   |__peptidyl-aspartic acid modification(+) 1 rec.
                                 |   |__peptidyl-cysteine modification(+) 1 rec.
                                 |   |__peptidyl-glutamic acid modification(+) 6 rec.
                                 |   |__peptidyl-glutamine modification(+) 1 rec.
                                 |   |__peptidyl-glycine modification(+)
                                 |   |__peptidyl-histidine modification(+) 9 rec.
                                 |   |__peptidyl-isoleucine modification
                                 |   |__peptidyl-L-amino acid racemization(+)
                                 |   |__peptidyl-leucine modification
                                 |   |__peptidyl-lysine modification(+) 32 rec.
                                 |   |__peptidyl-methionine modification(+) 2 rec.
                                 |   |__peptidyl-phenylalanine modification(+)
                                 |   |__peptidyl-proline modification(+) 5 rec.
                                 |   |__peptidyl-selenocysteine modification
                                 |   |__peptidyl-serine modification(+) 3 rec.
                                 |   |__peptidyl-threonine modification(+)
                                 |   |__peptidyl-tryptophan modification
                                 |   |__peptidyl-tyrosine modification(+)
                                 |   |__peptidyl-valine modification
                                 |__post-translational protein modification 350 rec.
                                 |   |__C-terminal protein amino acid modification(+)
                                 |   |__N-terminal protein amino acid propionylation
                                 |   |__post-translational protein acetylation
                                 |   |__protein auto-ADP-ribosylation
                                 |   |__protein modification by small protein conjugation or removal(+) 334 rec.
                                 |   |__protein poly-ADP-ribosylation
                                 |   |__regulation of post-translational protein modification(+) 29 rec.
                                 |__protein acylation 13 rec.
                                 |   |__peptidyl-lysine butyrylation
                                 |   |__peptidyl-lysine crotonylation(+)
                                 |   |__peptidyl-lysine glutarylation
                                 |   |__peptidyl-lysine propionylation
                                 |   |__protein acetylation(+) 12 rec.
                                 |   |__protein decanoylation
                                 |   |__protein formylation(+)
                                 |   |__protein malonylation
                                 |   |__protein myristoylation(+)
                                 |   |__protein octanoylation(+)
                                 |   |__protein palmitoleylation
                                 |   |__protein palmitoylation(+) 1 rec.
                                 |   |__protein succinylation
                                 |__protein alkylation 9 rec.
                                 |   |__protein methylation(+) 9 rec.
                                 |__protein arginylation
                                 |__protein carbamoylation
                                 |__protein carboxylation
                                 |   |__peptidyl-glutamic acid carboxylation
                                 |__protein de-ADP-ribosylation
                                 |   |__peptidyl-glutamate ADP-deribosylation
                                 |   |__peptidyl-serine ADP-deribosylation
                                 |__protein deacylation 1 rec.
                                 |   |__protein deacetylation(+)
                                 |   |__protein deglutarylation
                                 |   |__protein demalonylation(+)
                                 |   |__protein depalmitoleylation 1 rec.
                                 |   |__protein depalmitoylation
                                 |   |__protein depropionylation
                                 |   |__protein desuccinylation(+)
                                 |__protein dealkylation
                                 |   |__protein demethylation(+)
                                 |__protein deamination
                                 |   |__N-terminal protein amino acid deamination, from amino carbon
                                 |__protein deglutathionylation
                                 |__protein deglycation
                                 |   |__peptidyl-arginine deglycation
                                 |   |__peptidyl-cysteine deglycation
                                 |   |__peptidyl-lysine deglycation
                                 |   |__protein deglycation, glyoxal removal
                                 |   |__protein deglycation, methylglyoxal removal
                                 |__protein deglycosylation 3 rec.
                                 |   |__protein deglycosylation involved in glycoprotein catabolic process(+)
                                 |   |__protein demannosylation(+) 2 rec.
                                 |__protein dehydration
                                 |   |__peptidyl-tyrosine dehydrogenation
                                 |__protein delipidation
                                 |__protein denucleotidylation 1 rec.
                                 |   |__protein deadenylylation 1 rec.
                                 |__protein dephosphorylation 23 rec.
                                 |   |__peptidyl-histidine dephosphorylation
                                 |   |__peptidyl-N-phospho-arginine dephosphorylation 1 rec.
                                 |   |__peptidyl-serine dephosphorylation
                                 |   |__peptidyl-threonine dephosphorylation
                                 |   |__peptidyl-tyrosine dephosphorylation(+)
                                 |   |__regulation of translational initiation by eIF2 alpha dephosphorylation(+)
                                 |__protein flavinylation
                                 |__protein glutathionylation
                                 |   |__regulation of protein glutathionylation(+)
                                 |__protein hydroxylation 3 rec.
                                 |   |__peptidyl-aspartic acid hydroxylation
                                 |   |__peptidyl-lysine hydroxylation(+) 1 rec.
                                 |   |__peptidyl-proline hydroxylation(+)
                                 |   |__peptidyl-tyrosine hydroxylation
                                 |__protein lipidation 1 rec.
                                 |   |__C-terminal protein lipidation(+)
                                 |   |__N-terminal protein lipidation(+) 1 rec.
                                 |   |__protein decanoylation
                                 |   |__protein myristoylation(+)
                                 |   |__protein octanoylation(+)
                                 |   |__protein palmitoleylation
                                 |   |__protein palmitoylation(+) 1 rec.
                                 |   |__protein stearoylation
                                 |   |__regulation of protein lipidation(+)
                                 |__protein nitrosylation
                                 |   |__peptidyl-cysteine S-nitrosylation(+)
                                 |__protein nucleotidylation 1 rec.
                                 |   |__protein adenylylation(+) 1 rec.
                                 |   |__protein guanylylation
                                 |   |__protein uridylylation(+)
                                 |__protein oxidation
                                 |   |__peptidyl-cysteine oxidation
                                 |   |__peptidyl-lysine oxidation
                                 |   |__regulation of protein oxidation(+)
                                 |__protein phosphopantetheinylation
                                 |   |__peptidyl-serine phosphopantetheinylation
                                 |__protein phosphorylation 65 rec.
                                 |   |__I-kappaB phosphorylation(+)
                                 |   |__inhibitory G protein-coupled receptor phosphorylation(+)
                                 |   |__JUN phosphorylation
                                 |   |__peptidyl-arginine phosphorylation
                                 |   |__peptidyl-aspartic acid phosphorylation(+)
                                 |   |__peptidyl-histidine phosphorylation
                                 |   |__peptidyl-serine phosphorylation(+) 3 rec.
                                 |   |__peptidyl-threonine phosphorylation(+)
                                 |   |__peptidyl-tyrosine phosphorylation(+)
                                 |   |__protein autophosphorylation(+) 7 rec.
                                 |   |__regulation of protein phosphorylation(+) 12 rec.
                                 |   |__regulation of translational initiation by eIF2 alpha phosphorylation(+)
                                 |__protein polyamination
                                 |__protein prenylation
                                 |   |__protein farnesylation
                                 |   |__protein geranylgeranylation(+)
                                 |__protein sialylation
                                 |__protein sulfation
                                 |   |__peptidyl-tyrosine sulfation
                                 |__protein sulfhydration
                                 |   |__peptidyl-cystine sulfhydration
                                 |__protein-coenzyme A linkage
                                 |   |__protein-phosphoribosyl dephospho-coenzyme A linkage
                                 |__protein-FAD linkage 2 rec.
                                 |__protein-pyridoxal-5-phosphate linkage
                                 |   |__protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine
                                 |   |__regulation of protein-pyridoxal-5-phosphate linkage(+)
                                 |__regulation of protein modification process 42 rec.
                                     |__negative regulation of protein modification process(+) 8 rec.
                                     |__positive regulation of protein modification process(+) 24 rec.
                                     |__regulation of peptidyl-cysteine S-nitrosylation(+)
                                     |__regulation of peptidyl-lysine crotonylation(+)
                                     |__regulation of post-translational protein modification(+) 29 rec.
                                     |__regulation of protein acetylation(+)
                                     |__regulation of protein adenylylation(+)
                                     |__regulation of protein deacetylation(+)
                                     |__regulation of protein geranylgeranylation(+)
                                     |__regulation of protein glutathionylation(+)
                                     |__regulation of protein lipidation(+)
                                     |__regulation of protein oxidation(+)
                                     |__regulation of protein phosphorylation(+) 12 rec.
                                     |__regulation of protein polyglycylation(+) 1 rec.
                                     |__regulation of protein-pyridoxal-5-phosphate linkage(+)
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a protein metabolic process
macromolecule modification
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "cellular protein modification process" EXACT
    "process resulting in protein modification" EXACT
    "protein modification" EXACT
Secondary IDs
hide External Crossreferences & Linkouts