FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term Cdc48p-Npl4p-Vms1p AAA ATPase complex ID (Ontology) GO:0036266 (Gene Ontology)
Definition A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p.[ PubMed:21070972 PubMed:21936843 ]
Also Known As "Cdc48p-Npl4p-Vms1p complex" ; "Vms1-Cdc48-Npl4 complex" ; "Vms1p-Cdc48p-Npl4p complex"
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mitochondrial outer membrane______________
membrane protein complex__________________|
mitochondrial protein-containing complex__|
                                          outer mitochondrial membrane protein complex
                                           |__Cdc48p-Npl4p-Vms1p AAA ATPase complex
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Is a outer mitochondrial membrane protein complex
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Synonyms
  • "Cdc48p-Npl4p-Vms1p complex" EXACT
    "Vms1-Cdc48-Npl4 complex" EXACT
    "Vms1p-Cdc48p-Npl4p complex" EXACT
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