FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term calcitriol biosynthetic process from calciol ID (Ontology) GO:0036378 (Gene Ontology)
Definition Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.[ PubMed:17426122 PubMed:20511049 ]
Also Known As "calcitriol biosynthesis from calciol" ; "vitamin D3 activation"
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steroid biosynthetic process
 |__vitamin D biosynthetic process________
polyol metabolic process                  |
 |__polyol biosynthetic process___________|
vitamin D metabolic process               |
 |__vitamin D biosynthetic process________|
 |__vitamin D3 metabolic process__________|
fat-soluble vitamin biosynthetic process  |
 |__vitamin D biosynthetic process________|
alcohol biosynthetic process              |
 |__polyol biosynthetic process___________|
secondary alcohol metabolic process       |
 |__vitamin D3 metabolic process__________|
                                          calcitriol biosynthetic process from calciol
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Is a vitamin D biosynthetic process
polyol biosynthetic process
vitamin D3 metabolic process
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Synonyms
  • "1alpha,25(OH)2D3 biosynthesis" BROAD
    "1alpha,25-dihydroxycholecalciferol biosynthesis" BROAD
    "1alpha,25-dihydroxyvitamin D3 biosynthesis" BROAD
    "calcitriol biosynthesis from calciol" EXACT
    "vitamin D3 activation" EXACT[ PubMed:20506379 ]
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