FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term PERK-mediated unfolded protein response ID (Ontology) GO:0036499 (Gene Ontology)
Definition The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.[ PubMed:22013210 PubMed:27629041 ]
Also Known As "endoplasmic reticulum unfolded protein response; PERK signaling" ; "PERK branch of UPR" ; "PKR-like ER kinase signal transduction" (for all, see Synonyms field below)
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       2
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 Genes
 PERK-mediated unfolded protein response (all annotations which use CV term, excluding "NOT" statements)       2
     involved_in | PERK-mediated unfolded protein response       2
Spanning Tree (Parents/Children)
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cellular response to stress
 |__integrated stress response signaling_____________
cellular response to unfolded protein                |
 |__endoplasmic reticulum unfolded protein response__|
response to endoplasmic reticulum stress             |
 |__endoplasmic reticulum unfolded protein response__|
intracellular signal transduction                    |
 |__ER-nucleus signaling pathway_____________________|
 |__endoplasmic reticulum unfolded protein response__|
intracellular signaling cassette                     |
 |__integrated stress response signaling_____________|
                                                     PERK-mediated unfolded protein response  2 rec.
                                                      |__regulation of PERK-mediated unfolded protein response
                                                          |__negative regulation of PERK-mediated unfolded protein response
                                                          |__positive regulation of PERK-mediated unfolded protein response
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Is a ER-nucleus signaling pathway
endoplasmic reticulum unfolded protein response
integrated stress response signaling
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Synonyms
  • "EIF2AK3-mediated unfolded protein response" RELATED
    "endoplasmic reticulum unfolded protein response; PERK signaling" EXACT
    "eukaryotic translation initiation factor 2-alpha kinase 3-mediated unfolded protein response" RELATED
    "PERK branch of UPR" EXACT
    "PERK signal transduction pathway" BROAD
    "PERK signaling in response to endoplasmic reticulum stress" RELATED
    "PKR-like ER kinase signal transduction" EXACT[ PubMed:22013210 ]
    "UPR signaling by PERK stress sensor" EXACT
Secondary IDs
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Reactome:R-HSA-381042 "PERK regulates gene expression"