FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term ATF6-mediated unfolded protein response ID (Ontology) GO:0036500 (Gene Ontology)
Definition The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.[ PubMed:22013210 ]
Also Known As "activating transcription factor 6 signaling in unfolded protein response" ; "ATF6 branch of UPR" ; "endoplasmic reticulum unfolded protein response; ATF6 signaling" (for all, see Synonyms field below)
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cellular response to unfolded protein
 |__endoplasmic reticulum unfolded protein response__
response to endoplasmic reticulum stress             |
 |__endoplasmic reticulum unfolded protein response__|
intracellular signal transduction                    |
 |__ER-nucleus signaling pathway_____________________|
 |__endoplasmic reticulum unfolded protein response__|
                                                     ATF6-mediated unfolded protein response
                                                      |__regulation of ATF6-mediated unfolded protein response
                                                          |__negative regulation of ATF6-mediated unfolded protein response
                                                          |__positive regulation of ATF6-mediated unfolded protein response
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Is a ER-nucleus signaling pathway
endoplasmic reticulum unfolded protein response
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Synonyms
  • "activating transcription factor 6 signaling in unfolded protein response" EXACT
    "ATF6 branch of UPR" EXACT
    "ATF6 signal transduction pathway" BROAD
    "ATF6 signaling in response to endoplasmic reticulum stress" RELATED
    "ATF6-alpha UPR branch" NARROW
    "ATF6-beta UPR branch" NARROW
    "endoplasmic reticulum unfolded protein response; ATF6 signaling" EXACT
    "UPR signaling by ATF6 stress sensor" EXACT
Secondary IDs
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Reactome:R-HSA-381033 "ATF6 (ATF6-alpha) activates chaperones"