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| Term | ATF6-mediated unfolded protein response | ID (Ontology) | GO:0036500 (Gene Ontology) |
| Definition | The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.[ PubMed:22013210 ] | ||
| Also Known As | "activating transcription factor 6 signaling in unfolded protein response" ; "ATF6 branch of UPR" ; "endoplasmic reticulum unfolded protein response; ATF6 signaling" (for all, see Synonyms field below) | ||
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response to endoplasmic reticulum stress |__endoplasmic reticulum unfolded protein response__ intracellular signal transduction | |__ER-nucleus signaling pathway_____________________| |__endoplasmic reticulum unfolded protein response__| ATF6-mediated unfolded protein response |
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ER-nucleus signaling pathway endoplasmic reticulum unfolded protein response |
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| Reactome:R-HSA-381033 "ATF6 (ATF6-alpha) activates chaperones" | |||
