FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term ERAD pathway ID (Ontology) GO:0036503 (Gene Ontology)
Definition The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.[ PubMed:20940304 PubMed:21969857 ]
Also Known As "endoplasmic reticulum-associated degradation" ; "protein degradation by ERAD"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      39
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 Genes
 ERAD pathway (all annotations which use CV term, excluding "NOT" statements)      39
     involved_in | ERAD pathway      39
Spanning Tree (Parents/Children)
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protein catabolic process
 |__proteasomal protein catabolic process__________
cellular response to stress                        |
 |__response to endoplasmic reticulum stress_______|
response to stimulus                               |
 |__response to chemical___________________________|
proteolysis involved in protein catabolic process  |
 |__proteasomal protein catabolic process__________|
                                                   ERAD pathway  46 rec.
                                                    |__maintenance of unfolded protein involved in ERAD pathway
                                                    |__regulation of ERAD pathway 4 rec.
                                                    |   |__negative regulation of ERAD pathway 2 rec.
                                                    |   |__positive regulation of ERAD pathway 2 rec.
                                                    |__retrograde protein transport, ER to cytosol 4 rec.
                                                    |   |__membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
                                                    |   |__regulation of retrograde protein transport, ER to cytosol(+) 1 rec.
                                                    |__ubiquitin-dependent glycoprotein ERAD pathway 3 rec.
                                                        |__mannose trimming involved in glycoprotein ERAD pathway
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Is a proteasomal protein catabolic process
response to endoplasmic reticulum stress
response to chemical
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Synonyms
  • "endoplasmic reticulum-associated degradation" EXACT[ PubMed:22535891 ]
    "endoplasmic reticulum-associated protein degradation pathway" RELATED
    "ER-associated degradation pathway" RELATED[ PubMed:24699081 ]
    "protein degradation by ERAD" EXACT
Secondary IDs
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