General Information
Term	negative regulation of insulin receptor signaling pathway by insulin receptor internalization	ID (Ontology)	GO:0038014 (Gene Ontology)
Definition	Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation.[ PubMed:18492485 PubMed:7821727 PubMed:7978876 PubMed:9609114 ]
Also Known As	"negative regulation of insulin receptor signalling pathway by insulin receptor internalization"
Comment
Links to External Ontologies
	QuickGO data AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
No relevant records available
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available

General Information

Term

negative regulation of insulin receptor signaling pathway by insulin receptor internalization

ID (Ontology)

GO:0038014 (Gene Ontology)

Definition

Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation.[ PubMed:18492485 PubMed:7821727 PubMed:7978876 PubMed:9609114 ]

Also Known As

"negative regulation of insulin receptor signalling pathway by insulin receptor internalization"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

negative regulation of signal transduction
 |__negative regulation of signal transduction by receptor internalization__
 |__negative regulation of insulin receptor signaling pathway_______________|
receptor internalization                                                    |
 |__insulin receptor internalization________________________________________|
regulation of signal transduction by receptor internalization               |
 |__negative regulation of signal transduction by receptor internalization__|
regulation of insulin receptor signaling pathway                            |
 |__negative regulation of insulin receptor signaling pathway_______________|
negative regulation of cellular response to insulin stimulus                |
 |__negative regulation of insulin receptor signaling pathway_______________|
                                                                            negative regulation of insulin receptor signaling pathway by insulin receptor internalization

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	negative regulation of signal transduction by receptor internalization insulin receptor internalization negative regulation of insulin receptor signaling pathway
Part of
Synonyms & Secondary IDs
Synonyms
	"agonist-stimulated insulin receptor internalization" BROAD[ PubMed:18492485 ] "negative regulation of insulin receptor signalling pathway by insulin receptor internalization" EXACT
Secondary IDs

External Crossreferences & Linkouts

Spanning Tree View Settings

Parents/Children
View Depth

Relationships

Is a

negative regulation of signal transduction by receptor internalization
insulin receptor internalization
negative regulation of insulin receptor signaling pathway

Part of

Synonyms & Secondary IDs

Synonyms

"agonist-stimulated insulin receptor internalization" BROAD[ PubMed:18492485 ]
"negative regulation of insulin receptor signalling pathway by insulin receptor internalization" EXACT

Secondary IDs

External Crossreferences & Linkouts