FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term p38MAPK cascade ID (Ontology) GO:0038066 (Gene Ontology)
Definition A MAPK cascade containing at least the p38MAPK (MAPK14) MAP kinase, or Hog1 in yeast. It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of p38MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The p38MAPK cascade is activated by stress signals, including hyperosmolarity, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.[ PubMed:20811974 PubMed:23125017 PubMed:32794416 ]
Also Known As "p38 cascade" ; "p38 MAPK cascade"
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       6
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 Genes
 p38MAPK cascade (all annotations which use CV term, excluding "NOT" statements)       6
     involved_in | p38MAPK cascade       6
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  intracellular signaling cassette
   |__MAPK cascade
       |__p38MAPK cascade  8 rec.
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Is a MAPK cascade
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Synonyms
  • "MAPK14 cascade" RELATED
    "osmosensory signaling MAPK cascade" NARROW
    "p38 cascade" EXACT[ PubMed:20811974 ]
    "p38 MAPK cascade" EXACT
Secondary IDs
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Reactome:R-HSA-450302 "activated TAK1 mediates p38 MAPK activation"