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| Term | Kit signaling pathway | ID (Ontology) | GO:0038109 (Gene Ontology) |
| Definition | The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.[ PubMed:16129412 ] | ||
| Also Known As | "Kit signalling pathway" ; "SCF signaling pathway" ; "stem cell factor receptor signaling pathway" (for all, see Synonyms field below) | ||
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cell surface receptor signaling pathway |__cytokine-mediated signaling pathway______________________________ enzyme-linked receptor protein signaling pathway | |__cell surface receptor protein tyrosine kinase signaling pathway__| Kit signaling pathway |
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| Is a |
cell surface receptor protein tyrosine kinase signaling pathway cytokine-mediated signaling pathway |
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| Part of | cellular response to stem cell factor stimulus | ||
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